UbiProt: a database of ubiquitylated proteins.
UbiProt: a database of ubiquitylated proteins.
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DOI：
10.1186/1471-2105-8-126
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发表时间：
2007-04-18
影响因子：
3
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中科院分区：
文献类型：
--
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翻译后蛋白质泛素化修饰是现代生物学中最热门的话题之一，因为它对多种代谢途径产生巨大影响，并参与严重人类疾病的发病机制。大量的真核生物蛋白质被发现被泛素化。然而，关于特定泛素化蛋白的数据是相当抽象的。为了满足收集和系统化有关泛素化的实验数据的一般需要，我们开发了一个新的资源，UbiProt数据库，一个泛素化蛋白质的知识库。该数据库包含有关特定蛋白质的整体特征、泛素化特征、相关泛素化和去泛素化机制以及反映泛素化实验证据的参考文献的可检索信息。UbiProt可在免费获得。UbiProt数据库是一个公共资源，提供关于泛素化蛋白质的全面信息。该资源可以作为泛蛋白领域的研究人员和那些处理他们感兴趣的特定泛素化蛋白的人的一般参考来源。UbiProt数据库的进一步开发预计将是参与泛素系统研究的研究小组的共同兴趣。
Post-translational protein modification with ubiquitin, or ubiquitylation, is one of the hottest topics in a modern biology due to a dramatic impact on diverse metabolic pathways and involvement in pathogenesis of severe human diseases. A great number of eukaryotic proteins was found to be ubiquitylated. However, data about particular ubiquitylated proteins are rather disembodied. To fill a general need for collecting and systematizing experimental data concerning ubiquitylation we have developed a new resource, UbiProt Database, a knowledgebase of ubiquitylated proteins. The database contains retrievable information about overall characteristics of a particular protein, ubiquitylation features, related ubiquitylation and de-ubiquitylation machinery and literature references reflecting experimental evidence of ubiquitylation. UbiProt is available at for free. UbiProt Database is a public resource offering comprehensive information on ubiquitylated proteins. The resource can serve as a general reference source both for researchers in ubiquitin field and those who deal with particular ubiquitylated proteins which are of their interest. Further development of the UbiProt Database is expected to be of common interest for research groups involved in studies of the ubiquitin system.