The impact of early childhood lead exposure on brain organization: A functional magnetic resonance imaging study of language function
The impact of early childhood lead exposure on brain organization: A functional magnetic resonance imaging study of language function
复制标题
DOI：
10.1542/peds.2006-0467
复制
发表时间：
2006-09-01
期刊：
影响因子：
8
通讯作者：
Lanphear, Bruce P.
中科院分区：
文献类型：
--
作者：
Yuan, Weihong;Holland, Scott K.;Lanphear, Bruce P.
目标。这项工作的目的是评估儿童铅暴露对语言功能和大脑组织的神经基质的长期影响。辛辛那提牵头研究的年轻人被招募来接受功能性磁共振图像扫描，同时执行动词生成任务。这些受试者从出生到幼儿期都受到跟踪，并有大量关于铅暴露、神经心理学和行为的记录。四十二名受试者提供了有用的成像数据。研究了大脑语言激活的部位、强度以及与儿童血铅浓度之间的相关性。结果。在调整潜在的混杂因素后，发现与布罗卡区相邻的左额叶皮层和包括韦尼克区在内的左侧颞中回的激活与儿童平均血铅水平较高的受试者的激活减弱显着相关，而在血铅水平较高的受试者中，韦尼克区的右半球同源区的代偿性激活增强。结论。这项研究表明，儿童时期的铅暴露对与语言功能相关的大脑重组具有显着且持久的影响。
OBJECTIVES. The purpose of this work was to assess the long-term impact of childhood lead exposure on the neurosubstrate of language function and brain organization.METHODS. Young adults from the Cincinnati Lead Study were recruited to undergo functional magnetic resonance image scanning while performing a verb generation task. These subjects have been followed from birth through early childhood with extensive documentation of lead exposure, neuropsychology, and behavior. Forty-two subjects provided useful imaging data. The locale, strength, and the correlation between brain language activation and childhood blood lead concentration were studied.RESULTS. After adjusting for potential confounders, the activation in left frontal cortex, adjacent to Broca's area, and left middle temporal gyrus, including Wernicke's area, were found to be significantly associated with diminished activation in subjects with higher mean childhood blood lead levels, whereas the compensatory activation in the right hemisphere homolog of Wernicke's area was enhanced in subjects with higher blood lead levels.CONCLUSION. This study indicates that childhood lead exposure has a significant and persistent impact on brain reorganization associated with language function.