Increased plasma and adipose tissue levels of ANGPTL8/Betatrophin and ANGPTL4 in people with hypertension.
Increased plasma and adipose tissue levels of ANGPTL8/Betatrophin and ANGPTL4 in people with hypertension.
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DOI：
10.1186/s12944-018-0681-0
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发表时间：
2018-03-01
影响因子：
4.5
通讯作者：
Abubaker J
中科院分区：
文献类型：
--
作者：
Abu-Farha M;Cherian P;Qaddoumi MG;AlKhairi I;Sriraman D;Alanbaei M;Abubaker J
高血压是心血管疾病 (CVD) 和 2 型糖尿病 (T2D) 的危险因素。血管生成素样蛋白 (ANGPTL)，主要是 ANGPTL3、ANGPTL4 和 ANGPTL8，由于它们在调节脂蛋白脂肪酶（循环中脂蛋白代谢的关键酶）活性中发挥作用，因此与血浆脂质含量增加相关。血脂异常是高血压发生的危险因素；然而，ANGPTL3、ANGPTL4 和 ANGPTL8 在高血压受试者中的作用尚未确定。本研究比较了年龄和体重指数匹配的患有和不患有高血压的受试者中 ANGPTL3、ANGPTL4 和 ANGPTL8 的血浆和脂肪组织水平。共有 119 名受试者入组，其中 69 名高血压受试者和 50 名非高血压受试者。通过 ELISA 测量 ANGPTL3、ANGPTL4 和 ANGPTL8 血浆水平，而通过实时 PCR 评估它们在脂肪组织中的水平。我们发现 ANGPTL4（202.49 ± 17.44 ng/mL 与 160.64 ± 10.36 ng/mL，p = 0.04）和 ANGPTL8 水平（2310.96 ± 194.88 pg/mL 与 194.88 pg/mL） 1583.35 ±138.27 pg/mL，p = 0.001）在高血压受试者中高于非高血压受试者。然而，ANGPTL3 水平在两个人群之间没有显着差异。同样，患有 T2D 和高血压的受试者中 ANGPTL4 和 ANGPTL8 水平也高于患有 T2D 但不患有高血压的受试者。此外，ANGPTL8 三分位数最高的人患高血压的几率较高（比值比 [OR] = 3.8，95% 置信区间 [CI] = （1.5-9.8），p 值 = 0.005。与其血浆水平类似，ANGPTL4 和 ANGPTL8 在脂肪组织中较高。总之，我们的数据表明高血压受试者血浆和脂肪组织中的 ANGPTL4 和 ANGPTL8 水平均升高。高血压受试者中 ANGPTL4 和 ANGPTL8 水平升高凸显了它们的潜在参与作用、它们作为高血压生物标志物的潜在作用以及鉴于它们在调节脂质代谢中的作用。
Hypertension is a risk factor for both cardiovascular diseases (CVDs) and type 2 diabetes (T2D). Angiopoietin-like proteins (ANGPTLs), mainly ANGPTL3, ANGPTL4 and ANGPTL8, are associated with increased plasma lipid content due to their role in regulating the activity of lipoprotein lipase, a key enzyme in metabolism of the lipoprotein in circulation. Dyslipidaemia is a risk factor for hypertension development; however, the roles of ANGPTL3, ANGPTL4 and ANGPTL8 in subjects with hypertension have not yet been established. This study compared the plasma and adipose tissue levels of ANGPTL3, ANGPTL4 and ANGPTL8 in age- and body mass index-matched subjects with and without hypertension. A total of 119 subjects, including 69 hypertensive and 50 non-hypertensive subjects, were enrolled. ANGPTL3, ANGPTL4 and ANGPTL8 plasma levels were measured by ELISA, whereas their levels in adipose tissue were assessed via real-time PCR. We found that ANGPTL4 (202.49 ± 17.44 ng/mL vs. 160.64 ± 10.36 ng/mL, p = 0.04) and ANGPTL8 levels (2310.96 ± 194.88 pg/mL vs. 1583.35 ± 138.27 pg/mL, p = 0.001) were higher in hypertensive subjects than non-hypertensive subjects. However, ANGPTL3 levels were not significantly different between the two populations. Similarly, ANGPTL4 and ANGPTL8 levels were also elevated in subjects with T2D and hypertension than in those with T2D but not hypertension. Additionally, people with highest tertiles of ANGPTL8 had higher odds of having hypertension (odd ratio [OR] = 3.8, 95% confidence interval [CI] = (1.5-9.8), p-Value = 0.005. Similar to its plasma levels, ANGPTL4 and ANGPTL8 were higher in adipose tissue. In conclusion, our data illustrate that ANGPTL4 and ANGPTL8 levels in both plasma and adipose tissues are increased in subjects with hypertension. The elevated levels of ANGPTL4 and ANGPTL8 in hypertensive subjects highlight their potential involvement, their potential role as biomarkers for hypertension and their therapeutic value in hypertension given their roles in regulating lipid metabolism.
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影响因子：
3.7
作者：
Abubaker J;Tiss A;Abu-Farha M;Al-Ghimlas F;Al-Khairi I;Baturcam E;Cherian P;Elkum N;Hammad M;John J;Kavalakatt S;Khadir A;Warsame S;Dermime S;Behbehani K;Dehbi M
通讯作者：
Dehbi M
ANGPTL3-4-8 模型，甘油三酯运输的分子机制。
影响因子：
5.8
作者：
Zhang R
通讯作者：
Zhang R
影响因子：
--
作者：
Gonzalez-Muniesa, Pedro;de Oliveira, Cristiane;Trayhurn, Paul
通讯作者：
Trayhurn, Paul
影响因子：
8.2
作者：
Espes, Daniel;Lau, Joey;Carlsson, Per-Ola
通讯作者：
Carlsson, Per-Ola
DOI：
10.1152/ajpendo.00084.2012
发表时间：
2012-08-01
影响因子：
5.1
作者：
Ren, Gang;Kim, Ji Young;Smas, Cynthia M.
通讯作者：
Smas, Cynthia M.