Effects of whey protein supplements on metabolism: evidence from human intervention studies
Effects of whey protein supplements on metabolism: evidence from human intervention studies
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DOI：
10.1097/mco.0b013e32834b89da
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发表时间：
2011-11-01
影响因子：
3.1
通讯作者：
Heer, Martina
中科院分区：
文献类型：
--
作者：
Graf, Sonja;Egert, Sarah;Heer, Martina
流行病学研究表明，牛奶和乳制品的消费与代谢紊乱和心血管疾病的风险降低呈负相关。特别是，乳清蛋白似乎诱导这些效果，因为生物活性化合物，如乳铁蛋白，免疫球蛋白，谷氨酰胺和乳白蛋白。此外，它还是分支链氨基酸的优良来源。本文综述了乳清蛋白对代谢紊乱和肌肉骨骼系统的影响的最新研究结果。最近的发现我们确定了25个最近发表的干预试验检查慢性和/或急性影响的乳清蛋白补充剂对脂质和葡萄糖代谢，血压，血管功能和肌肉骨骼系统。乳清蛋白似乎具有部分由肠促胰岛素介导的血糖和/或胰岛素降低作用。此外，乳清蛋白可以增加肌肉蛋白质的合成。相反，对血脂和脂蛋白、血压和血管功能没有明确的影响。对于骨代谢的数据是稀缺的。总结概括，乳清蛋白可能会影响葡萄糖代谢和肌肉蛋白质的合成。然而，临床疗效的证据还不足以就具体剂量和补充持续时间提出最终建议。
Purpose of reviewEpidemiological studies indicate that the consumption of milk and dairy products is inversely associated with a lower risk of metabolic disorders and cardiovascular diseases. In particular, whey protein seems to induce these effects because of bioactive compounds such as lactoferrin, immunoglobulins, glutamine and lactalbumin. In addition, it is an excellent source of branch chained amino acids. This review summarizes recent findings on the effects of whey protein on metabolic disorders and the musculoskeletal system.Recent findingsWe identified 25 recently published intervention trials examining chronic and/or acute effects of whey protein supplementation on lipid and glucose metabolism, blood pressure, vascular function and on the musculoskeletal system. Whey protein appears to have a blood glucose and/or insulin lowering effect partly mediated by incretins. In addition, whey protein may increase muscle protein synthesis. In contrast there are no clear-cut effects shown on blood lipids and lipoproteins, blood pressure and vascular function. For bone metabolism the data are scarce.SummaryIn summary, whey protein may affect glucose metabolism and muscle protein synthesis. However, the evidence for a clinical efficacy is not strong enough to make final recommendations with respect to a specific dose and the duration of supplementation.