Antenatal and neonatal factors contributing to extra uterine growth failure (EUGR) among preterm infants in Boston Birth Cohort (BBC).

Antenatal and neonatal factors contributing to extra uterine growth failure (EUGR) among preterm infants in Boston Birth Cohort (BBC).
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DOI:
10.1038/s41372-021-00948-4
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发表时间:
2021-05
期刊:
Journal of perinatology : official journal of the California Perinatal Association
影响因子:
--
通讯作者:
Wang X
Wang X
中科院分区:
其他
文献类型:
--
作者:
Makker K;Ji Y;Hong X;Wang X

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确定与宫外生长迟缓(EUGR)主要结局相关的产前和新生儿因素。 这项前瞻性队列研究纳入了来自英国围产期协作组(BBC)的一个亚组中的1063名早产儿。进行回归分析以评估EUGR与产前因素和新生儿因素的关联。 6.1%的婴儿出生时存在宫内生长受限(IUGR),21.7%的婴儿有EUGR。对于EUGR状态,校正后的比值比在出生体重(比值比0.99,p = 0.00,置信区间0.99 - 0.99)、出生时胎龄(比值比4.58,p = 0.00,置信区间3.25 - 6.44)、动脉导管未闭(PDA,比值比2.9,p = 0.02,置信区间1.17 - 7.1)、坏死性小肠结肠炎(NEC,比值比5.14,p = 0.012,置信区间1.44 - 18.3)以及达到全量喂养的日龄(比值比1.04,p = 0.001,置信区间1.01 - 1.06)方面具有显著性。 这项研究强调了与EUGR相关的重要因素。需要进一步的研究以获得更深入的了解。
Identify antenatal and neonatal factors associated with primary outcome of EUGR. 1063 preterm infants from a subset of the BBC were included in this prospective cohort study. Regression analysis was carried out to evaluate associations of EUGR with antenatal factors and neonatal factors. 6.1% of the infants had in-utero growth restriction (IUGR) at birth and 21.7% of infants had EUGR. The adjusted odds ratio for EUGR status were significant for birth weight (OR 0.99, p = 0.00, CI 0.99–0.99), for GA at birth (OR 4.58, p = 0.00, CI 3.25–6.44), for PDA (OR 2.9, p = 0.02, CI 1.17–7.1), for NEC (OR 5.14, p = 0.012, CI 1.44–18.3) and for day of life of reaching full feeds (OR 1.04, p = 0.001, CI 1.01–1.06). This study highlights important factors associated with EUGR. Additional studies are needed to gain further insight.
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