Computational modeling of fiber transport in human respiratory airways—A review
Computational modeling of fiber transport in human respiratory airways—A review
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DOI：
10.1007/s42757-020-0061-7
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发表时间：
2020-03
期刊：
影响因子：
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通讯作者：
L. Tian;G. Ahmadi
中科院分区：
文献类型：
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作者：
L. Tian;G. Ahmadi
在过去的几十年里，对空气中石棉、人造玻璃纤维和碳纳米纤维/碳纳米管的呼吸传输和沉积的研究一直很活跃。与吸入的球形颗粒相比，细长颗粒独特的针状几何形状已被确定为极端致癌的主要原因。因此，揭示这种颗粒独特的细长形状与其在人体呼吸系统中的传输特性之间的内在联系，对于了解纤维吸入毒性至关重要。目前，这些信息只能通过计算建模来提供。本文综述了纤维在人体呼吸道中传输的计算模型的研究现状。并对今后需要进一步研究的问题进行了讨论。
Investigations on the respiratory transport and deposition of airborne asbestos, man-made vitreous fibers (MMVFs), and carbon nanofiber/carbon nanotubes have been actively conducted in the past few decades. The elongated particles’ distinctive needle-like geometry has been identified as the main cause of extreme carcinogenicity when compared to inhaled spherical particles. Consequently, uncovering the intrinsic relationship between the particle’s unique elongated shape and its transport characteristics in human respiratory systems is crucial for understanding fiber inhalation toxicity. Currently, such information can only be provided by computational modeling. This review summarized the current state of the art of computational modeling of fiber transport in the human respiratory tract. The needed future researches were also discussed.