paraneoplastic neurologic disorders in small cell lung carcinoma
paraneoplastic neurologic disorders in small cell lung carcinoma
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DOI：
10.1212/wnl.0000000000001721
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发表时间：
2015-07-21
期刊：
影响因子：
9.9
通讯作者：
Maddison, Paul
中科院分区：
文献类型：
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作者：
Gozzard, Paul;Woodhall, Mark;Maddison, Paul
目的：探讨神经副肿瘤性疾病和神经元抗体在小细胞肺癌中的发生频率和范围。方法：收集264例经手术病理证实的小细胞肺癌患者。所有患者均接受了全面的神经学检查。化疗前采集血清样本，分析15种神经元抗体。结果：PND发生率较高(24例，9.4%)，以Lambert-Eaton肌无力综合征(3.8%)、感觉神经元病(1.9%)、边缘脑炎(1.5%)最常见。87%的PNDS患者有SOX2抗体(62.5%)、HUD抗体(41.7%)或P/Q VGCC抗体(50%)，无论他们的证候如何。其他神经元抗体的出现频率较低(GABAB受体[12.5%]和N型VGCC[20.8%])或极少数(GAD65、两面体、Ri、CRMP5、MA2、Yo、VGKC复合体、CASPR2、LGI1和NMDA受体[ALL
Objective:To determine the frequency and range of paraneoplastic neurologic disorders (PNDs) and neuronal antibodies in small cell lung carcinoma (SCLC).Methods:Two hundred sixty-four consecutive patients with biopsy-proven SCLC were recruited at the time of tumor diagnosis. All patients underwent full neurologic examination. Serum samples were taken prior to chemotherapy and analyzed for 15 neuronal antibodies. Thirty-eight healthy controls were analyzed in parallel.Results:PNDs were quite prevalent (n = 24, 9.4%), most frequently Lambert-Eaton myasthenic syndrome (3.8%), sensory neuronopathy (1.9%), and limbic encephalitis (1.5%). Eighty-seven percent of all patients with PNDs had antibodies to SOX2 (62.5%), HuD (41.7%), or P/Q VGCC (50%), irrespective of their syndrome. Other neuronal antibodies were found at lower frequencies (GABAb receptor [12.5%] and N-type VGCC [20.8%]) or very rarely (GAD65, amphiphysin, Ri, CRMP5, Ma2, Yo, VGKC complex, CASPR2, LGI1, and NMDA receptor [all