NMDA receptor blockade attenuates locomotion elicited by intrastriatal dopamine D1-receptor stimulation.
NMDA receptor blockade attenuates locomotion elicited by intrastriatal dopamine D1-receptor stimulation.
复制标题
NMDA 受体阻断会减弱纹状体内多巴胺 D1 受体刺激引起的运动。
DOI：
10.1002/syn.20035
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发表时间：
2004
期刊：
影响因子：
--
通讯作者：
Walker,PaulD
中科院分区：
文献类型：
--
作者：
Kreipke,ChristianW;Walker,PaulD
Previous behavioral studies suggest that the striatum mediates a hyperactive response to systemic NMDA receptor antagonism in combination with systemic D1 receptor stimulation. However, many experiments conducted at the cellular level suggest that inhibition of NMDA receptors should block D1 receptor‐mediated locomotor activity. Therefore, we investigated the consequences of NMDA receptor blockade on the ability of striatal D1 receptors to elicit locomotor activity using systemic and intrastriatal injections of the NMDA antagonist MK‐801 combined with intrastriatal injections of the D1 full agonist SKF 82958. Following drug treatment locomotor activity was measured via computerized activity monitors designed to quantify multiple parameters of rodent open‐field behavior. Both systemic (0.1 mg/kg) and intrastriatal (1.0 μg) MK‐801 pretreatments completely blocked locomotor and stereotypic activity elicited by 10 μg of SKF 82958 directly infused into the striatum. Further, increased activity triggered by intrastriatal SKF 82958 was attenuated by a posttreatment with intrastriatal infusion of 1 μg MK‐801. These data suggest that D1‐stimulated locomotor behaviors controlled by the striatum require functional NMDA channels. Synapse 53:28–35, 2004. © 2004 Wiley‐Liss, Inc.
