Draxin, a repulsive axon guidance protein, is involved in hippocampal development
Draxin, a repulsive axon guidance protein, is involved in hippocampal development
复制标题
DOI：
10.1016/j.neures.2009.09.1710
复制
发表时间：
2010-01-01
影响因子：
2.9
通讯作者：
Tanaka, Hideaki
中科院分区：
文献类型：
--
作者：
Zhang, Sanbing;Su, Yuhong;Tanaka, Hideaki
海马体在学习和记忆中起着至关重要的作用，是涉及神经疾病的主要部位之一。海马体在发育过程中的适当组织对其功能至关重要。我们发现，draxin是一种排斥性轴突引导线索，在发育中的海马中广泛表达，而draxin缺乏的小鼠海马更小，特别是在结构的前部。这种减少的量化显示，突变体的齿状回体积明显小于正常的对应体。这种大小的减小似乎依赖于细胞凋亡，而不是由于细胞分裂速率的降低。(C) 2009爱思唯尔爱尔兰有限公司和日本神经科学学会。版权所有。
The hippocampus plays an essential role in learning and memory and is one of the major sites implicated in neural diseases. The proper organization of the hippocampus during development is important for its function. We found that draxin, a repulsive axon guidance cue, was widely expressed in the developing hippocampus and draxin deficient mice possessed a smaller hippocampus, particularly in the anterior part of the structure. Quantification of this reduction revealed that the volume of the dentate gyrus of the mutant was significantly smaller compared to the normal counterpart. This size reduction seemed to be dependent on apoptosis rather than due to a decrease in the rate of cell division. (C) 2009 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.