Development of the metabolic syndrome in black and white adolescent girls: A longitudinal assessment
Development of the metabolic syndrome in black and white adolescent girls: A longitudinal assessment
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DOI：
10.1542/peds.2004-2358
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发表时间：
2005-11-01
期刊：
影响因子：
8
通讯作者：
Klein, DJ
中科院分区：
文献类型：
--
作者：
Morrison, JA;Friedman, LA;Klein, DJ
背景代谢综合征与2型糖尿病和心血管疾病的风险增加有关，在妊娠期间开始发展。我们试图在18岁和19岁的黑人和白色女孩中确定该综合征存在的早期预测因素。使用来自国家心脏，肺和血液研究所生长和健康研究（一项为期10年的队列研究）2个中心的参与者的纵向数据，我们应用成人治疗组III的截止值记录9岁和10岁女孩异常综合征元素和综合征患病率的变化，当病例罕见时，18岁和19岁的女孩，当患病率达到3%时。纵向回归模型确定了该综合征存在的早期预测因子。每个种族中只有1名女孩在9岁和10岁时有≥ 3个因子（0.2%），但10年后有20名黑人女孩（3.5%）和12名白色女孩（2.3%）患有该综合征。低高密度脂蛋白胆固醇是普遍存在的整个期间，在黑人和白色女孩。其他变量的患病率在入组时较低，但在随访期间增加，除了黑人女孩的甘油三酯水平异常，在整个随访期间仍然较低。在多变量模型中，腰围和甘油三酯水平的早期测量是综合征发展的重要预测因子。中心性肥胖与代谢综合征的发展密切相关，这表明旨在管理青少年前肥胖的早期干预可以降低发展综合征的风险。
Background. The metabolic syndrome, associated with increased risk of type 2 diabetes mellitus and cardiovascular disease, begins to develop during adolescence.Objective. We sought to identify early predictors of the presence of the syndrome at the ages of 18 and 19 years in black and white girls.Methods. Using longitudinal data on participants from 2 centers in the National Heart, Lung, and Blood Institute Growth and Health Study, a 10-year cohort study, we applied cutoffs from the Adult Treatment Panel III to document changes in the prevalence of abnormal syndrome elements and the syndrome in girls aged 9 and 10 years, when cases were rare, and those aged 18 and 19 years, when prevalence had reached 3%. Longitudinal regression models identified early predictors for the presence of the syndrome.Results. Only 1 girl of each race had >= 3 factors at ages 9 and 10 ( 0.2%), but 20 black girls ( 3.5%) and 12 white girls ( 2.3%) had the syndrome 10 years later. Low high-density lipoprotein cholesterol was prevalent throughout the period in both black and white girls. The prevalence of other variables was low at enrollment but increased during follow-up, except for abnormal triglyceride levels in black girls, which remained low throughout follow-up. In multivariate models, early measures of waist circumference and triglyceride level were significant predictors for development of the syndrome.Conclusion. The strong association of central adiposity with the development of the metabolic syndrome suggests that early interventions aimed at managing pre-teen obesity could reduce risk of developing the syndrome.