Dietary PUFA and the metabolic syndrome in Indian Asians living in the UK
Dietary PUFA and the metabolic syndrome in Indian Asians living in the UK
复制标题
DOI：
10.1079/pns2003318
复制
发表时间：
2004-02-01
影响因子：
7
通讯作者：
Lovegrove, JA
中科院分区：
文献类型：
--
作者：
Brady, LM;Williams, CM;Lovegrove, JA
生活在英国的印度亚洲人的冠心病死亡率比本土白人高50%，这不能归因于传统的风险因素。相反，代谢综合征的特征，包括升高的血浆三酰甘油、降低的HDL-胆固醇（HDL-C）和增加的小密度LDL颗粒的比例，连同胰岛素抵抗和中心性肥胖，在该人群中普遍存在。本综述检查证据，以支持这一假设的不平衡，在饮食中的多不饱和脂肪酸的摄入量，特别是较高的n-6多不饱和脂肪酸的摄入量与较低的长链（LC）n-3多不饱和脂肪酸的摄入量相结合，起着重要的作用，在印度的亚洲人中观察到的代谢综合征的患病率。数据来说明操纵的背景n-6多不饱和脂肪酸的摄入量（中度或高n-6多不饱和脂肪酸）和随后的反应，以补充LC n-3多不饱和脂肪酸对血脂和胰岛素的作用在一组印度亚洲志愿者的影响。结果表明，补充LC n-3 PUFA对那些食用中等或高n-6 PUFA饮食的受试者的胰岛素作用没有影响。在餐后阶段减少血浆三酰甘油浓度更大的高n-6 PUFA背景饮食补充鱼油。本研究的结论是，与中心假设相反，与高加索人相比，印度亚洲人代谢异常的患病率可能不是由于n-6和n-3 PUFA摄入量的差异造成的。
Indian Asians living in the UK have a 50% higher CHD mortality rate compared with the indigenous Caucasian population, which cannot be attributed to traditional risk factors. Instead, features of the metabolic syndrome, including raised plasma triacylglycerol, reduced HDL-cholesterol (HDL-C) and an increased proportion of small dense LDL particles, together with insulin resistance and central obesity, are prevalent among this population. The present review examines evidence to support the hypothesis that an imbalance in dietary PUFA intake, specifically a higher intake of n-6 PUFA in combination with a lower intake of the long-chain (LC) n-3 PUFA, plays an important role in the prevalence of the metabolic syndrome observed in Indian Asians. Data are presented to illustrate the impact of manipulation of the background n-6 PUFA intake (moderate or high n-6 PUFA) and the subsequent response to supplementation with LC n-3 PUFA on blood lipids and insulin action in a group of Indian Asian volunteers. The results demonstrate that supplementation with LC n-3 PUFA had no impact on insulin action in those subjects consuming either the moderate-or high-n-6 PUFA diet. In the postprandial phase reductions in plasma triacylglycerol concentrations were greater in those consuming the high-n-6 PUFA background diet subsequent to fish oil supplementation. The present study concludes that, contrary to the central hypothesis, the prevalence of metabolic abnormalities in Indian Asians compared with Caucasians may not be attributable to differences in intakes of n-6 and n-3 PUFA.