Effect of metals on mutagenesis and DNA repair.
Effect of metals on mutagenesis and DNA repair.
复制标题
金属对诱变和 DNA 修复的影响。
DOI：
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发表时间：
1981
影响因子：
10.4
通讯作者：
T. Rossman
中科院分区：
文献类型：
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作者：
T. Rossman
与有机化合物的情况不同，金属在致癌性和诱变性之间没有很高的相关性。由于DNA模板的改变，降低DNA聚合酶的保真度，或抑制DNA复制的校对，药物可能会引起DNA的错误复制，从而产生诱变作用。此外，细菌有一个诱导的，容易出错的DNA修复系统（SOS修复），其活性导致突变。在研究得最好的金属诱变例子铬酸盐中，几乎没有证据表明SOS系统的参与。金属可以通过抑制由另一种物质引起的DNA损伤的修复而起到促进作用。亚砷酸盐已经证明了这一点。标准筛选方法无法检测到致变剂。
Unlike the situation with organic compounds, metals do not show a high correlation between carcinogenicity and mutagenicity. An agent may be mutagenic by causing misreplication of DNA due to alterations of the DNA template, decreased fidelity of DNA polymerase, or inhibition of the proofreading of DNA replication. In addition, bacteria have an inducible, error-prone DNA repair system (SOS repair) whose activity results in mutagenesis. In the best studied example of metal mutagenesis, chromate, there is little evidence for the involvement of the SOS system. Metals may act as comutagens by inhibiting the repair of damage to DNA caused by another agent. This has been demonstrated for arsenite. Comutagens would not be detected by standard screening methods.