Sumoylation at the host-pathogen interface.
Sumoylation at the host-pathogen interface.
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DOI：
10.3390/biom2020203
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发表时间：
2012-04-05
期刊：
影响因子：
5.5
通讯作者：
Wilson VG
中科院分区：
文献类型：
--
作者：
Wilson VG
许多病毒蛋白质已被证明是sumoylated与相应的调节作用，其蛋白质的功能，这表明这种宿主细胞修饰过程被广泛利用的病毒病原体控制病毒的活性。除了使用类小泛素化来调节它们自身的蛋白质之外，已经显示了几种病毒病原体调节总体宿主类小泛素化水平。鉴于SUMO添加的大量细胞靶标和通过SUMO化调节的关键细胞过程的广度，病毒对总体SUMO化的调节可能改变细胞环境，以确保其有利于病毒繁殖和/或持久性。像一些病毒一样，某些细菌性植物病原体也靶向类小泛素化系统，通常减少类小泛素化以破坏宿主的抗病原体反应。最近的证据表明，单核细胞增生李斯特菌也破坏宿主类小泛素化，这是需要有效的感染，扩展了植物病原体的观察，人类病原体，并表明，病原体调节宿主类小泛素化可能比以前认识到的更广泛。这篇综述将集中在病原体如何调节宿主类小泛素化系统以及这如何使病原体受益的最新方面。
Many viral proteins have been shown to be sumoylated with corresponding regulatory effects on their protein function, indicating that this host cell modification process is widely exploited by viral pathogens to control viral activity. In addition to using sumoylation to regulate their own proteins, several viral pathogens have been shown to modulate overall host sumoylation levels. Given the large number of cellular targets for SUMO addition and the breadth of critical cellular processes that are regulated via sumoylation, viral modulation of overall sumoylation presumably alters the cellular environment to ensure that it is favorable for viral reproduction and/or persistence. Like some viruses, certain bacterial plant pathogens also target the sumoylation system, usually decreasing sumoylation to disrupt host anti-pathogen responses. The recent demonstration that Listeria monocytogenes also disrupts host sumoylation, and that this is required for efficient infection, extends the plant pathogen observations to a human pathogen and suggests that pathogen modulation of host sumoylation may be more widespread than previously appreciated. This review will focus on recent aspects of how pathogens modulate the host sumoylation system and how this benefits the pathogen.