Centromere DNA, proteins and kinetochore assembly in vertebrate cells
Centromere DNA, proteins and kinetochore assembly in vertebrate cells
复制标题
DOI：
10.1023/b:chro.0000036590.96208.83
复制
发表时间：
2004-01-01
影响因子：
2.6
通讯作者：
Fukagawa, T
中科院分区：
文献类型：
--
作者：
Fukagawa, T
着丝粒是染色体上的一个特化区域，在真核细胞有丝分裂和减数分裂过程中对染色体的忠实分离至关重要。它是着丝粒（负责微管结合和染色体运动的功能性核蛋白复合物）通过复杂分子机制组装的位点。在此，我回顾了最近的进展，我们的理解着丝粒DNA作为网站的着丝粒组装和背后的机制在脊椎动物细胞中的着丝粒组装。
The centromere is a specialized region of the chromosome that is essential for faithful chromosome segregation during mitosis and meiosis in eukaryotic cells. It is the site at which the kinetochore, the functional nucleoprotein complex responsible for microtubule binding and chromosome movement, is assembled through complex molecular mechanisms. Herein, I review recent advances in our understanding of centromeric DNAs as sites for kinetochore assembly and the mechanisms underlying kinetochore assembly in vertebrate cells.