ANTIBODIES TO PARATHYROID HORMONE-RELATED PROTEIN LOWER SERUM-CALCIUM IN ATHYMIC MOUSE MODELS OF MALIGNANCY-ASSOCIATED HYPERCALCEMIA DUE TO HUMAN-TUMORS
ANTIBODIES TO PARATHYROID HORMONE-RELATED PROTEIN LOWER SERUM-CALCIUM IN ATHYMIC MOUSE MODELS OF MALIGNANCY-ASSOCIATED HYPERCALCEMIA DUE TO HUMAN-TUMORS
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DOI：
10.1172/jci113794
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发表时间：
1988-11-01
影响因子：
15.9
通讯作者：
MARTIN, TJ
中科院分区：
文献类型：
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作者：
KUKREJA, SC;SHEVRIN, DH;MARTIN, TJ
甲状旁腺素相关蛋白（PTHrP）最近已从与高钙血症相关的肿瘤中分离出来。在本研究中，我们测试了PTHrP的中和抗血清对恶性肿瘤相关高钙血症的两种动物模型的血清钙和尿cAMP的影响。动物模型由（a）人鳞状细胞肺癌和（B）人喉癌组成，两者均在无胸腺小鼠中连续进行。抗血清特异性地降低了荷瘤动物中升高的血清钙和尿cAMP水平。我们的结论是PTHrP在恶性肿瘤相关性高钙血症的发病机制中起着重要作用。
A parathyroid hormone-related protein (PTHrP) has recently been isolated from tumors associated with hypercalcemia. In the present study, we tested the effects of neutralizing antisera to the PTHrP on serum calcium and urine cAMP in two animal models of malignancy-associated hypercalcemia. The animal models consisted of (a) a human squamous cell lung cancer and (b) a human laryngeal cancer, both serially carried in athymic mice. The antisera specifically reduced the elevated serum calcium and urinary cAMP levels in the tumor-bearing animals. We conclude that PTHrP plays a major role in the pathogenesis of malignancy-associated hypercalcemia.