Human Excretion of Polybrominated Diphenyl Ether Flame Retardants: Blood, Urine, and Sweat Study.
Human Excretion of Polybrominated Diphenyl Ether Flame Retardants: Blood, Urine, and Sweat Study.
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DOI：
10.1155/2017/3676089
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发表时间：
2017
影响因子：
--
通讯作者：
Genuis SJ
中科院分区：
文献类型：
--
作者：
Genuis SK;Birkholz D;Genuis SJ
多溴二苯醚 (PBDE) 通常用作阻燃剂，在环境、动物和人类中经常被检测到。尽管人们越来越认识到这些持久性有机污染物对健康有严重影响，尤其是对儿童而言，但据我们所知，这是第一项旨在调查人类消除生物累积性多溴二苯醚干预措施的研究。目标。确定血液、尿液和汗液作为 PBDE 生物监测介质的功效；评估尿液和汗液中五种常见 PBDE 同系物（28、47、99、100 和 153）的排泄；并探索诱导出汗减少生物累积 PBDE 的潜力。结果。尿液样本中未发现 PBDE 同系物；研究结果集中在血液和汗液上。 80% 的参与者在一种或多种体液中检测出 PBDE 28 呈阳性，100% 的参与者检测出 PBDE 47 呈阳性，95% 的参与者检测出 PBDE 99 呈阳性，90% 的参与者检测出 PBDE 100 和 PBDE 153 呈阳性。诱导排汗促进了五种同源物的排泄，不同同源物的排泄率不同。结论。血液检测只能部分了解人体 PBDE 的生物累积情况；血液和汗液的测试可以提供更好的了解。这项研究为定期诱导排汗作为治疗性消除 PBDE 的潜在手段提供了重要的基线证据。多溴二苯醚暴露的胎儿毒性和生殖影响凸显了进一步解毒研究的重要性。
Commonly used as flame retardants, polybrominated diphenyl ethers (PBDEs) are routinely detected in the environment, animals, and humans. Although these persistent organic pollutants are increasingly recognized as having serious health implications, particularly for children, this is the first study, to our knowledge, to investigate an intervention for human elimination of bioaccumulated PBDEs. Objectives. To determine the efficacy of blood, urine, and perspiration as PBDE biomonitoring mediums; assess excretion of five common PBDE congeners (28, 47, 99, 100, and 153) in urine and perspiration; and explore the potential of induced sweating for decreasing bioaccumulated PBDEs. Results. PBDE congeners were not found in urine samples; findings focus on blood and perspiration. 80% of participants tested positive in one or more body fluids for PBDE 28, 100% for PBDE 47, 95% for PBDE 99, and 90% for PBDE 100 and PBDE 153. Induced perspiration facilitated excretion of the five congeners, with different rates of excretion for different congeners. Conclusion. Blood testing provides only a partial understanding of human PBDE bioaccumulation; testing of both blood and perspiration provides a better understanding. This study provides important baseline evidence for regular induced perspiration as a potential means for therapeutic PBDE elimination. Fetotoxic and reproductive effects of PBDE exposure highlight the importance of further detoxification research.
影响因子：
10.4
作者：
Brown VJ
通讯作者：
Brown VJ