Defining the syntax for self-assembling RNA tertiary architectures.
Defining the syntax for self-assembling RNA tertiary architectures.
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定义自组装 RNA 三级架构的语法。
DOI：
10.1093/nass/nrp042
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发表时间：
2009
期刊：
影响因子：
--
通讯作者：
Jaeger,Luc
中科院分区：
文献类型：
--
作者：
Jaeger,Luc
稳定的RNA是模块化和分层的三维（3D）架构，利用重复出现的结构基序形成广泛的非共价三级相互作用（1，2）。使用已知的RNA的X射线结构的比较序列和结构分析，目前可以收集RNA的折叠和组装原理，以生成用于合理设计和预测RNA 3D形状的原型语言的语法。RNA结构学是指破译这种原始语言，并使用它来构建具有自组装特性的新功能RNA形状（3-5）。因此，这种方法可以有助于预测和合理设计RNA的三级结构，在纳米技术，合成生物学和医学的潜在应用。
Stable RNAs are modular and hierarchical three-dimensional (3D) architectures taking advantage of recurrent structural motifs to form extensive non-covalent tertiary interactions (1, 2). Using comparative sequence and structural analysis of known X-ray structures of RNAs, folding and assembly principles of RNA can presently be gathered to generate the syntax of a proto-language for rational design and prediction of RNA 3D shapes. RNA architectonics refers to the deciphering of this proto-language and to its use to build new functional RNA shapes with self-assembly properties (3-5). This approach can therefore contribute to the prediction and rational design of RNA tertiary structures for potential applications in nanotechnology, synthetic biology and medicine.