Notoamides F-K, Prenylated Indole Alkaloids Isolated from a Marine-Derived Aspergillus sp.
Notoamides F-K, Prenylated Indole Alkaloids Isolated from a Marine-Derived Aspergillus sp.
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DOI：
10.1021/np800471y
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发表时间：
2008-12-01
影响因子：
5.1
通讯作者：
Ohta, Tomihisa
中科院分区：
文献类型：
--
作者：
Tsukamoto, Sachiko;Kato, Hikaru;Ohta, Tomihisa
从海洋曲霉菌中分离得到6个新的异戊烯化吲哚生物碱，命名为notoamides F-K（8-13），通过波谱方法确定了它们的结构。Notoamide I（11）对HeLa细胞显示出弱的细胞毒性，IC（50）值为21 μ g/mL。
Six new prenylated indole alkaloids, named notoamides F-K (8-13), were isolated from a marine-derived Aspergillus sp. Their structures, including absolute configurations, were elucidated by spectroscopic methods. Notoamide I (11) showed weak cytotoxicity against HeLa cells with an IC(50) value of 21 mu g/mL.