Ischemia-induced neural stem/progenitor cells express pyramidal cell markers
Ischemia-induced neural stem/progenitor cells express pyramidal cell markers
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DOI：
10.1097/wnr.0b013e32834acb54
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发表时间：
2011-11-16
期刊：
影响因子：
1.7
通讯作者：
Matsuyama, Tomohiro
中科院分区：
文献类型：
--
作者：
Clausen, Martijn;Nakagomi, Takayuki;Matsuyama, Tomohiro
成人脑源性神经干细胞作为一种持久的神经细胞来源，可用于缺血性中风等多种神经系统疾病的中枢神经系统修复，已引起人们的广泛关注。最近，我们在中风后的小鼠大脑皮层中发现了损伤诱导的神经干/祖细胞。在这项研究中，我们发现，在体外分化后，损伤诱导的神经干/祖细胞表达锥体细胞标记物Emx1和CaMKII α，以及成熟神经元标记物MAP2和Tuj1。脑卒中皮层中的5-溴-2-脱氧尿苷阳性神经元也表达这种锥体标记物。脑卒中后新再生的锥体神经元的存在可能为脑卒中功能恢复治疗提供一种无创治疗策略。NeuroReport 22:789-794 (C) 2011 Wolters Kluwer Health垂直bar Lippincott Williams & Wilkins。
Adult brain-derived neural stem cells have acquired a lot of interest as an endurable neuronal cell source that can be used for central nervous system repair in a wide range of neurological disorders such as ischemic stroke. Recently, we identified injury-induced neural stem/progenitor cells in the poststroke murine cerebral cortex. In this study, we show that, after differentiation in vitro, injury-induced neural stem/progenitor cells express pyramidal cell markers Emx1 and CaMKII alpha, as well as mature neuron markers MAP2 and Tuj1. 5-bromo-2-deoxyuridinine-positive neurons in the peristroke cortex also express such pyramidal markers. The presence of newly regenerated pyramidal neurons in the poststroke brain might provide a noninvasive therapeutic strategy for stroke treatment with functional recovery. NeuroReport 22:789-794 (C) 2011 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.