Marriage of Scintillator and Semiconductor for Synchronous Radiotherapy and Deep Photodynamic Therapy with Diminished Oxygen Dependence
Marriage of Scintillator and Semiconductor for Synchronous Radiotherapy and Deep Photodynamic Therapy with Diminished Oxygen Dependence
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闪烁体和半导体的结合用于同步放射治疗和深度光动力治疗，减少氧依赖性
DOI：
10.1002/anie.201408472
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发表时间：
2015-02-02
影响因子：
16.6
通讯作者：
Shi, Jianlin
中科院分区：
文献类型：
--
作者：
Zhang, Chen;Zhao, Kuaile;Shi, Jianlin
光动力疗法(PDT)临床应用面临的两大挑战是对氧的强烈依赖性和穿透深度的限制。相比之下，电离辐射的穿透性太强，在临床上往往会因为肿瘤区域缺乏有效的能量积累而导致放射治疗效率低下。受PDT和RT优势互补的启发，我们提出将闪烁体和半导体相结合作为电离辐射诱导的PDT试剂，实现同步放射治疗和深度不敏感的PDT，同时减少对氧的依赖。在核壳结构的掺Ce-III的LiYF4@SiO_2@ZnO结构中，掺Ce-III的LiYF_4纳米闪烁体在电离辐射下的下转换紫外荧光使纳米氧化锌中产生电子-空穴(e(-)-h(+))对，从而产生生物毒性的羟基自由基。这一过程类似于I型PDT过程，以增强抗肿瘤治疗效果。
Strong oxygen dependence and limited penetration depth are the two major challenges facing the clinical application of photodynamic therapy (PDT). In contrast, ionizing radiation is too penetrative and often leads to inefficient radiotherapy (RT) in the clinic because of the lack of effective energy accumulation in the tumor region. Inspired by the complementary advantages of PDT and RT, we present herein the integration of a scintillator and a semiconductor as an ionizing-radiation-induced PDT agent, achieving synchronous radiotherapy and depth-insensitive PDT with diminished oxygen dependence. In the core-shell Ce-III-doped LiYF4@SiO2@ZnO structure, the downconverted ultraviolet fluorescence from the Ce-III-doped LiYF4 nanoscintillator under ionizing irradiation enables the generation of electron-hole (e(-)-h(+)) pairs in ZnO nanoparticles, giving rise to the formation of biotoxic hydroxyl radicals. This process is analogous to a typeI PDT process for enhanced antitumor therapeutic efficacy.