Comparative evaluation of subgingivally delivered 1.2% rosuvastatin and 1% metformin gel in treatment of intrabony defects in chronic periodontitis: A randomized controlled clinical trial
Comparative evaluation of subgingivally delivered 1.2% rosuvastatin and 1% metformin gel in treatment of intrabony defects in chronic periodontitis: A randomized controlled clinical trial
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DOI：
10.1002/jper.17-0434
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发表时间：
2018-11-01
影响因子：
4.3
通讯作者：
Pradeep, A. R.
中科院分区：
文献类型：
--
作者：
Pankaj, Dileep;Sahu, Ipshita;Pradeep, A. R.
背景：本研究的目的是探讨和比较局部给予1.2%瑞舒伐他汀（RSV）和1%二甲双胍（MF）凝胶作为刮治和根规划（SRP）辅助治疗慢性牙周炎患者骨内缺损的临床疗效。方法：90名志愿者随机分为3个治疗组；1) SRP加安慰剂凝胶；2) SRP加1.2% RSV凝胶；3) SRP加1% MF凝胶。在基线、6月和12月记录改良沟出血指数（mSBI）、斑块指数（PI）、口袋探测深度（PD）和临床附着水平（CAL）等临床参数，并在6月和12月进行骨缺损填充的影像学评估。结果：所有组的mSBI、BP、PD和CAL均有改善，但RSV组和MF组PD、CAL增加和骨填充百分比的平均减少均高于安慰剂组。结论：与安慰剂凝胶相比，辅助使用局部输送的1.2% RSV和1% MF凝胶可显著减少PD，增加CAL和改善骨填充。使用1.2% RSV凝胶的效果明显优于1% MF凝胶。
Background: The aim of this study is to explore and compare the clinical efficacy of locally delivered 1.2% Rosuvastatin (RSV) and 1% Metformin (MF) gel as an adjunct to scaling and root planning (SRP) in the treatment of intrabony defects in chronic periodontitis patients.Methods: A total of 90 volunteers were randomly assigned to three treatment groups; 1) SRP plus placebo gel; 2) SRP plus 1.2% RSV gel; 3) SRP plus 1% MF gel. Clinical parameters like modified sulcus bleeding index (mSBI), plaque index (PI), pocket probing depth (PD) and clinical attachment level (CAL) were recorded at baseline, 6 and 12 months and the radiologic assessment of bone defect fill was performed at 6 and 12 months.Results: mSBI, BP, PD, and CAL were improved in all the groups, however mean reductions in PD, CAL gain, and percentage of bone fill was found to be higher in RSV and MF groups than placebo group at all visits.Conclusion: Adjunctive use of locally delivered 1.2% RSV and 1% MF gel stimulates a significant PD reduction, CAL gains and improved bone fill when compared with placebo gel. Results were significantly better with the use of 1.2% RSV gel than 1% MF gel.