Clinical and virologic characteristics of chronic active Epstein-Barr virus infection
Clinical and virologic characteristics of chronic active Epstein-Barr virus infection
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DOI：
10.1182/blood.v98.2.280
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发表时间：
2001-07-15
期刊：
影响因子：
20.3
通讯作者：
Morishima, T
中科院分区：
文献类型：
--
作者：
Kimura, H;Hoshino, Y;Morishima, T
对30例慢性活动性EB病毒（CAEBV）感染患者进行了分析。研究组包括18名男性和12名女性患者，年龄范围为5至31岁，平均年龄为14.2岁。并非所有患者均具有高滴度的EBV特异性抗体，但所有患者的外周血中均具有高病毒载量（超过10（2.5）拷贝/μ g DNA）。50%的患者显示染色体畸变，79%具有EBV单克隆性。根据患者外周血中主要感染的细胞是T细胞还是自然杀伤（NK）细胞，将患者分为2个临床上不同的组。在68个月的观察期内，10名患者死于肝功能衰竭、恶性淋巴瘤或其他原因。T细胞型CAEBV患者的生存时间短于NK细胞型疾病患者。(C)2001年，美国血液学会。
Thirty patients with chronic active Epstein-Barr virus (CAEBV) infection were analyzed. The study group included 18 male and 12 female patients, ranging in age from 5 to 31 years with a mean age of 14.2 years. Not all patients had high titers of EBV-specific antibodies, but ail patients had high viral loads in their peripheral blood (more than 10(2.5) copies/mug DNA), Fifty percent of the patients displayed chromosomal aberrations, and 79% had monoclonality of EBV. Patients were divided into 2 clinically distinct groups, based on whether the predominantly infected cells in their peripheral blood were T cells or natural killer (NK) cells. Over a 68-month period of observation, 10 patients died from hepatic failure, malignant lymphoma, or other causes. Patients with T-cell CAEBV had a shorter survival time than those with NK-cell type of disease. (C) 2001 by The American Society of Hematology.