An efficient [4 + 2 + 1] entry to seven-membered rings.
An efficient [4 + 2 + 1] entry to seven-membered rings.
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DOI：
10.1021/ja046147y
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发表时间：
2004-08
影响因子：
15
通讯作者：
Y. Ni;J. Montgomery
中科院分区：
文献类型：
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作者：
Y. Ni;J. Montgomery
提出了一种镍催化的三甲基硅基重氮甲烷与二烯上的炔烃[4+2+1]环加成反应的新方法。广泛的不饱和底物参与该序列，并且立体选择性通常很好。提出了三种可能的机理，每一种都涉及到瞬时镍卡宾物种的生成。
A new nickel-catalyzed procedure for the [4 + 2 + 1] cycloaddition of trimethylsilyl diazomethane with alkynes tethered to dienes has been developed. A broad range of unsaturated substrates participate in the sequence, and stereoselectivities are generally excellent. Three possible mechanisms are proposed, and each involves the generation of a transient nickel carbene species.