Effect of vitamin B complex on neurotransmission and neurite outgrowth
Effect of vitamin B complex on neurotransmission and neurite outgrowth
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DOI：
10.1016/0306-3623(95)02072-1
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发表时间：
1996-09-01
期刊：
影响因子：
--
通讯作者：
Yamamoto, H
中科院分区：
文献类型：
--
作者：
Fujii, A;Matsumoto, H;Yamamoto, H
1. The effect of vitamin B complex (vitamin B-1, B-6 and B-12) was studied on nerve conduction velocity in acrylamide-neuropathy rats maintained on refined semisynthetic complete vitamin and vitamin B-deficient diets in vivo and on neurite outgrowth in vitro using cells obtained from dorsal root ganglions of mice.2. Acrylamide neuropathy was clearer in the group maintained on a refined semisynthetic vitamin B-deficient diet than in those on a refined semisynthetic complete vitamin diet. The neurotoxicity was lowest in the group given vitamin B complex prophylactic-therapeutically, next higher following therapeutic administration and last with no vitamin B complex administration in both groups maintained on a refined semisynthetic vitamin B deficient diet and a refined semisynthetic complete vitamin diet.3. The nerve conduction velocity tended to decrease by treatment with acrylamide. The decrement of nerve conduction velocity was partially inhibited by vitamin B complex. No significant difference was found in the groups treated with acrylamide and given vitamin B complex prophylastic-therapeutically and the control (no acrylamide treatment) in the group maintained on a refined semisynthetic vitamin B deficient diet.4. The greatest neurite outgrowth was found in the group treated with vitamins BI, B-6 and B-12-enriched medium, follow ed by the groups of vitamin B-12-enriched and vitamin B-1-enriched media. All groups treated with a vitamin B-enriched medium had significantly greater (P
