In vivo anti-inflammatory effect and toxicological screening of Maytenus heterophylla and Maytenus senegalensis extracts
In vivo anti-inflammatory effect and toxicological screening of Maytenus heterophylla and Maytenus senegalensis extracts
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DOI：
10.1177/0960327110379242
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发表时间：
2011-07-01
影响因子：
2.8
通讯作者：
Silva, O.
中科院分区：
文献类型：
--
作者：
da Silva, G.;Tanica, M.;Silva, O.
杂叶梅藤（Eckl & Zeyh.）罗布森和塞内加尔Maytenus senegalensis （Lam）Exell是两种非洲药用植物，用于治疗疼痛和炎症性疾病。我们评估了海苔叶、茎和根提取物以及塞内加尔海苔叶和茎提取物的体内抗炎活性。此外，我们评估了它们的体内急性和亚急性毒性。采用角叉菜胶诱导足跖水肿法测定乙醇提取物对Wistar白化大鼠的抗炎作用。对成年雄性CD-6小鼠进行急性和亚急性毒性筛选。龙井草和龙井草叶提取物具有显著的抗炎活性（120 mg/kg, per os），分别减少51%和35%的水肿。在1200 mg/kg剂量下，太子参提取物无毒，而太子参提取物有一定的毒性。我们的研究结果显示，在局部急性炎症模型中，异叶橐吾和塞内加尔橐吾叶提取物都具有显著的抗炎作用，并表明异叶橐吾叶提取物没有急性和亚急性毒性迹象（但塞内加尔橐吾叶提取物没有）。今后的研究必将进一步阐明该活性提取物的作用机制，并建立其化学指纹图谱。
Maytenus heterophylla (Eckl & Zeyh.) Robson and Maytenus senegalensis (Lam). Exell are two African medicinal plants used to treat painful and inflammatory diseases. We evaluated the in vivo (per os) anti-inflammatory activity of M. heterophylla leaf, stem and root extracts and of M. senegalensis leaf and stem extracts. Additionally, we assessed their in vivo acute and sub-acute toxicities. Anti-inflammatory activities of ethanol extracts were determined in Wistar albino rats, by the carrageenan-induced paw oedema method. Acute and sub-acute toxicity screening of the extracts was evaluated in adult male CD-6 mice. Leaf extracts of M. heterophylla and M. senegalensis exhibited significant anti-inflammatory activity (120 mg/kg, per os), reducing oedema by 51% and 35%, respectively. While M. heterophylla extracts at 1200 mg/kg have shown to be non-toxic, M. senegalensis extracts indicated some toxicity. Our results show a significant anti-inflammatory effect of both M. heterophylla and M. senegalensis leaf extracts in a local model of acute inflammation and suggest the absence of acute and sub-acute toxicity signs of the M. heterophylla leaf extract (but not of M. senegalensis). Ongoing studies will surely shed some light into the mechanism of action of this active extract and establish its chemical fingerprint.