High density lipoproteins and atherosclerosis: emerging aspects.
High density lipoproteins and atherosclerosis: emerging aspects.
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DOI：
10.3724/sp.j.1263.2011.12282
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发表时间：
2012-12
期刊：
影响因子：
--
通讯作者：
Norata GD
中科院分区：
文献类型：
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作者：
Sala F;Catapano AL;Norata GD
高密度脂蛋白（HDL）促进过量胆固醇从外周组织流出到肝脏排泄。这种能力是HDL最相关的抗动脉粥样硬化作用的原因。HDL促进胆固醇流出的能力还导致调节动脉粥样硬化中涉及的免疫细胞（包括单核细胞-巨噬细胞、B和T淋巴细胞）中的一系列应答。此外，在炎症期间，这类脂蛋白的组成在很大程度上变化，从而促进功能失调的HDL的形成。本文就高密度脂蛋白在动脉粥样硬化形成过程中对免疫细胞和免疫炎症介质的调节作用进行综述。
High density lipoproteins (HDL) promote the efflux of excess cholesterol from peripheral tissues to the liver for excretion. This ability is responsible for the most relevant anti-atherogenic effect of HDL. The ability of HDL to promote cholesterol efflux results also in the modulation of a series of responses in the immune cells involved in atherosclerosis, including monocyte-macrophages, B and T lymphocytes. Furthermore, during inflammation, the composition of this class of lipoproteins varies to a large extent, thus promoting the formation of dysfunctional HDL. The aim of this review is to discuss the emerging role of HDL in modulating the activity of immune cells and immune-inflammatory mediators during atherogenesis.