Effect of aerobic exercise training dose on liver fat and visceral adiposity
Effect of aerobic exercise training dose on liver fat and visceral adiposity
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DOI：
10.1016/j.jhep.2015.02.022
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发表时间：
2015-07-01
影响因子：
25.7
通讯作者：
Johnson, Nathan A.
中科院分区：
文献类型：
--
作者：
Keating, Shelley E.;Hackett, Daniel A.;Johnson, Nathan A.
背景与目的：有氧运动减少肝脏脂肪和内脏脂肪组织（VAT）。然而，来自随机试验的数据有限，无法为运动规划建议提供信息。本研究采用随机安慰剂对照设计，检查了常用处方运动剂量对降低肝脏脂肪和VAT的有效性。方法：不活动和超重/肥胖成人接受8周的以下任一项：i）低至中等强度，高容量有氧运动（LO：HI，50%VO2峰值，60分钟，4天/周）; ii）高强度，低容量有氧运动（HI：LO，70%VO2峰值，45分钟，3天/周）; iii）低至中等强度、低容量有氧运动（LO：LO，50%VO2峰值，45分钟，3天/周）;或iv）安慰剂（PLA）。肝脂肪（光谱）和增值税（磁共振成像）进行了测量之前和之后intervention.Results：47的48（n = 12，每组）参与者完成了试验。未发生严重不良事件。肝脏脂肪的组x时间相互作用发生了显著变化，HI：LO降低了2.38 +/-0.73%，LO：HI降低了2.62 +/-1.00%，LO：LO降低了0.84 +/- 0.47%，但PLA没有（增加1.10 +/- 0.62%）（p = 0.04）。HI：LO（-258.38 +/- 87.78 cm（3））、LO：HI（-386.80 +/- 119.5 cm（3））和LO：LO（-212.96 +/- 105.54 cm（3））的VAT显著降低，但PLA（92.64 +/- 83.46 cm（3））未显著降低（p = 0.03）。运动方案的剂量或强度与肝脏脂肪或VAT的减少之间没有显著差异（p > 0.05）。结论：本研究发现，无论是有氧运动剂量还是强度，肝脏脂肪减少的功效都没有差异。所有的有氧运动方案都减少了少量的肝脏脂肪和VAT，而没有临床上显著的体重减轻。(C)2015年欧洲肝脏研究协会。Elsevier B. V.出版，保留所有权利。
Background & Aims: Aerobic exercise reduces liver fat and visceral adipose tissue (VAT). However, there is limited data from randomized trials to inform exercise programming recommendations. This study examined the efficacy of commonly prescribed exercise doses for reducing liver fat and VAT using a randomized placebo-controlled design.Methods: Inactive and overweight/obese adults received 8 weeks of either; i) low to moderate intensity, high volume aerobic exercise (LO:HI, 50% VO2peak, 60 min, 4 d/week); ii) high intensity, low volume aerobic exercise (HI:LO, 70% VO2peak, 45 min, 3 d/week); iii) low to moderate intensity, low volume aerobic exercise (LO:LO, 50% VO2peak, 45 min, 3 d/week); or iv) placebo (PLA). Liver fat (spectroscopy) and VAT (magnetic resonance imaging) were measured before and after intervention.Results: Forty-seven of the 48 (n = 12 in each group) participants completed the trial. There were no serious adverse events. There was a significant change in group x time interaction in liver fat, which reduced in HI:LO by 2.38 +/- 0.73%, in LO:HI by 2.62 +/- 1.00%, and in LO:LO by 0.84 +/- 0.47% but not in PLA (increase of 1.10 +/- 0.62%) (p = 0.04). There was a significant reduction in VAT in HI:LO (-258.38 +/- 87.78 cm(3)), in LO:HI (-386.80 +/- 119.5 cm(3)), and in LO:LO (-212.96 +/- 105.54 cm(3)), but not in PLA (92.64 +/- 83.46 cm(3)) (p = 0.03). There were no significant differences between the dose or intensity of the exercise regimen and reductions in liver fat or VAT (p > 0.05).Conclusion: The study found no difference in efficacy of liver fat reduction by either aerobic exercise dose or intensity. All of the aerobic exercise regimens employed reduced liver fat and VAT by a small amount without clinically significant weight loss. (C) 2015 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.