Transportin 1 in the mouse brain : appearance in regions of neurogenesis, cerebrospinal fluid production/sensing, and circadian clock., 519 : 1770-1780, 2011
Transportin 1 in the mouse brain : appearance in regions of neurogenesis, cerebrospinal fluid production/sensing, and circadian clock., 519 : 1770-1780, 2011
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小鼠大脑中的转运蛋白 1：在神经发生、脑脊液产生/传感和生物钟区域中的出现。, 519 : 1770-1780, 2011
DOI：
10.1002/cne.22600
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发表时间：
2011
影响因子：
2.5
通讯作者：
Sato M; Okamura H
中科院分区：
文献类型：
--
作者：
Oyama S;Fujino H;Yamazaki R;Okura I;Regan JW;Awata A;Arai T;Murayama T.;Sato M; Okamura H
Transportin1 (Tnpo1) is a carrier protein belonging to the importin‐β family, which transports substrates between the cytoplasm and the nucleus. To gain insight into the role ofTnpo1gene in the brain, we investigated the localization ofTnpo1‐,Tnpo2‐, andTnpo3‐expressing cells by in situ hybridization histochemistry.Tnpo1mRNA‐positive cells were distributed throughout the brain from the olfactory bulb to the medulla oblongata. The cells in the subventricular zone of the lateral ventricle, where neurogenesis occurs even in the adult, and its progeny neurons in the granular cells of the olfactory bulb and the islands of Calleja were strongly labeled. It is also noteworthy that cerebrospinal fluid (CSF)‐generating epithelial cells in the choroid plexus and CSF‐contacting and ‐sensing circumventricular organs, including organum vasculosum lamina terminalis, subfornical organ, and subcommissural organ, expressed high amounts ofTnpo1. The strongest signals were found in the suprachiasmatic nucleus (SCN), where the biological clock resides, which prompted us to examine the circadian characteristics ofTnpo1. Under constant‐dark conditions, the circadian expression profiles ofTnpo1mRNA in the SCN showed a peak in the subjective night and a trough in the subjective day.Tnpo2andTnpo3showed similar patterns of expression, except in the choroids plexus, the subventricular zone, and the SCN, where the expression was notably weaker. These findings suggest thatTnpo1is involved in a variety of functions in the adult brain, including neurogenesis, CSF production and sensing, and circadian rhythms. J. Comp. Neurol. 519:1770‐1780, 2011. © 2011 Wiley‐Liss, Inc.
