Mobile genetic elements in Acinetobacter antibiotic-resistance acquisition and dissemination.
Mobile genetic elements in Acinetobacter antibiotic-resistance acquisition and dissemination.
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DOI：
10.1111/nyas.14918
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发表时间：
2022-12
影响因子：
5.2
通讯作者：
Palmer, Lauren D.
中科院分区：
文献类型：
--
作者：
Noel, Hannah R.;Petrey, Jessica R.;Palmer, Lauren D.
致病性不动杆菌，最著名的是鲍曼不动杆菌，是全球医疗保健相关感染的重要原因。由于不动杆菌的高耐药率和广泛的耐药率，不动杆菌感染对全球健康特别令人担忧。广泛的基因组测序和分析已经确定，细菌对抗生素的耐药性通常是通过移动的遗传元件获得和传播的，这些遗传元件包括插入序列(IS)、转座子、整合子和接合质粒。在不动杆菌中，对碳青霉烯类和头孢菌素类的耐药性与IS高度相关，因为许多伊萨巴元件编码强大的外向启动子，这是充分表达β-内酰胺酶以赋予临床耐药性所必需的。在这里，我们通过耐药获得机制的框架和实验验证的机制来综述移动遗传元件在不动杆菌耐药中的作用。致病性不动杆菌是全世界医疗保健相关感染的重要原因。不动杆菌感染由于多重耐药率高和广泛耐药而特别令人担忧。细菌对抗生素的耐药性通常是通过移动的遗传元件获得和传播的，这些遗传元件包括插入序列、转座子、整合子和接合质粒。我们回顾了移动遗传元件在不动杆菌耐药中的作用。
Pathogenic Acinetobacter species, most notably Acinetobacter baumannii, are a significant cause of healthcare‐associated infections worldwide. Acinetobacter infections are of particular concern to global health due to the high rates of multidrug resistance and extensive drug resistance. Widespread genome sequencing and analysis has determined that bacterial antibiotic resistance is often acquired and disseminated through the movement of mobile genetic elements, including insertion sequences (IS), transposons, integrons, and conjugative plasmids. In Acinetobacter specifically, resistance to carbapenems and cephalosporins is highly correlated with IS, as many ISAba elements encode strong outwardly facing promoters that are required for sufficient expression of β‐lactamases to confer clinical resistance. Here, we review the role of mobile genetic elements in antibiotic resistance in Acinetobacter species through the framework of the mechanism of resistance acquisition and with a focus on experimentally validated mechanisms. Pathogenic Acinetobacter species are a significant cause of healthcare‐associated infections worldwide. Acinetobacter infections are of particular concern due to the high rates of multidrug resistance and extensive drug resistance. Bacterial antibiotic resistance is often acquired and disseminated through movement of mobile genetic elements including insertion sequences, transposons, integrons, and conjugative plasmids. We review the role of mobile genetic elements in antibiotic resistance in Acinetobacter species.
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