Inhalation of hydrogen gas protects against myocardial stunning and infarction in swine
Inhalation of hydrogen gas protects against myocardial stunning and infarction in swine
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DOI：
10.3109/14017431.2012.659676
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发表时间：
2012-06-01
影响因子：
2.2
通讯作者：
Sumikawa, Koji
中科院分区：
文献类型：
--
作者：
Sakai, Kazuyuki;Cho, Sungsam;Sumikawa, Koji
目标。本研究旨在确定吸入氢气 (H-2) 是否可以保护猪的心肌免受缺血再灌注 (I/R) 损伤。设计。在第一项研究中，在麻醉的开胸猪中，通过闭塞左冠状动脉前降支 (LAD) 12 分钟，然后再灌注 90 分钟来产生心肌顿抑。 A组在缺血再灌注时吸入100%氧气，B组吸入2%H-2加98%氧气。在第二项研究中，心肌梗死是由 LAD 闭塞 40 分钟，然后再灌注 120 分钟产生的。 C组在缺血和再灌注期间吸入100%氧气。 D组吸入2%H-2加98%氧气。 E组吸入4%H-2加96%氧气。结果。再灌注后 90 分钟，B 组的节段缩短 (%SS) 相对于基线的变化为 74 +/- 13 (平均值 +/- SD)%，显着高于 A 组 (48 +/- 15%)。 E 组的心肌梗塞面积 (32 +/- 10%)，但 D 组的心肌梗塞面积 (40 +/- 9%) 小于 C 组的心肌梗塞面积 (46 +/- 6%)。结论。吸入 2% H-2 气体可以改善猪的心肌顿抑，吸入 4% 但不是 2% H-2 气体可以减少猪的心肌梗塞面积。
Objectives. The present study was carried out to determine whether inhalation of hydrogen (H-2) gas protects myocardium against ischemia-reperfusion (I/R) injury in swine. Design. In anesthetized open-chest swine, myocardial stunning was produced by 12-minute occlusion of left anterior descending coronary artery (LAD) followed by 90-minute reperfusion in the first study. Group A inhaled 100% oxygen, and group B inhaled 2% H-2 plus 98% oxygen during ischemia and reperfusion. In the second study, myocardial infarction was produced by 40-minute occlusion of LAD followed by 120-minute reperfusion. Group C inhaled 100% oxygen during ischemia and reperfusion. Group D inhaled 2% H-2 plus 98% oxygen. Group E inhaled 4% H-2 plus 96% oxygen. Results. The change of segment shortening (%SS) from baseline at 90 minutes after reperfusion in group B was 74 +/- 13 (mean +/- SD) %, which was significantly higher than that in group A (48 +/- 15%). Myocardial infarct size in group E (32 +/- 10%), but not in group D (40 +/- 9%) was smaller than that in group C (46 +/- 6%). Conclusions. Inhalation of 2% H-2 gas improves myocardial stunning, and inhalation of 4% but not 2% H-2 gas reduces myocardial infarct size in swine.