GROWTH-INHIBITION AND REGRESSION OF HUMAN PROSTATE AND BREAST-TUMORS IN ATHYMIC MICE BY TEA EPIGALLOCATECHIN GALLATE
GROWTH-INHIBITION AND REGRESSION OF HUMAN PROSTATE AND BREAST-TUMORS IN ATHYMIC MICE BY TEA EPIGALLOCATECHIN GALLATE
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DOI：
10.1016/0304-3835(95)03948-v
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发表时间：
1995-09-25
期刊：
影响因子：
9.7
通讯作者：
HIIPAKKA, RA
中科院分区：
文献类型：
--
作者：
LIAO, SS;UMEKITA, Y;HIIPAKKA, RA
将人前列腺癌细胞系PC-3（雄激素不敏感）和LNCaP 104-R（雄激素抑制）皮下接种到裸鼠中以产生前列腺肿瘤。腹膜内注射绿色茶（-）表没食子儿茶素-3-没食子酸酯，但不与结构相关的儿茶素，如（-）表儿茶素-3-没食子酸酯，抑制裸鼠中人前列腺肿瘤的生长，并迅速缩小肿瘤的大小。（-）表没食子儿茶素-3-没食子酸酯还快速抑制由人乳腺癌细胞系MCF-7在裸鼠中形成的肿瘤生长。绿色茶的高消费量与某些亚洲国家前列腺癌和乳腺癌的低发病率之间可能存在某种关系。
The human prostate cancer cell lines, PC-3 (androgen-insensitive) and LNCaP 104-R (androgen-repressed) were inoculated subcutaneously into nude mice to produce prostate tumors. Intraperitoneal injection of green tea (-)epigallocatechin-3-gallate but not structurally related catechins, such as (-)epicatechin-3-gallate, inhibited the growth and rapidly reduced the size of human prostate tumors in nude mice. (-)Epigallocatechin-3-gallate also rapidly inhibited the growth of tumor growth formed by the human mammary cancer cell line MCF-7 in nude mice. It is possible that there is a relationship between the high consumption of green tea and the low incidence of prostate and breast cancers in some Asian countries.