Feasibility of mailed biomarker data collection among US young adults: Saliva-based cotinine and self-reported nicotine use
Feasibility of mailed biomarker data collection among US young adults: Saliva-based cotinine and self-reported nicotine use
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DOI：
10.1016/j.drugalcdep.2023.109791
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发表时间：
2023-02-06
影响因子：
4.2
通讯作者：
Mitchell, Colter
中科院分区：
文献类型：
--
作者：
Patrick, Megan E.;Parks, Michael J.;Mitchell, Colter
背景：具有全国代表性的自我报告研究是物质使用流行率数据的标准。新出现的生物标志物评估可以增加对暴露的客观测量。然而，生物标志物评估通常依赖于个人样本采集。目前的研究调查了全国样本中的年轻人是否愿意并能够通过邮件提供唾液样本，以及唾液样本中的可替宁与自我报告的吸电子烟和吸烟的对应关系。方法：为监测未来（MTF）电子烟补充计划收集数据，时间为2020年9月至11月。符合条件的参与者（N = 4358）是在2019年春季从MTF的美国12年级学生的全国代表性样本中选出的。MTF电子烟补充调查在12年级MTF调查一年后在全国范围内对个人进行了调查（2020年，平均年龄= 19.6岁；N =1244）。调查权重考虑了设计和人员流失。结果：在接受调查的人中，66.2%的人同意提供唾液样本，其中73.8%的人邮寄了样本。在提供任何人口统计学特征的唾液样本方面没有显着差异，但那些报告使用尼古丁的人不太可能提供样本。可替宁截断值bbb30 ng/mL和>0 ng/mL与自述值吻合良好。结论：本研究结果支持了在全国范围内邮寄唾液采集的可行性和所采集数据的有效性。这些发现支持未来的研究创新，以扩大现有的调查研究方案，包括在年轻人的代表性样本中收集生物标志物数据。
Background: Nationally representative self-report studies are the standard for data on the prevalence of substance use. Newly emerging biomarker assessments can add objective measurements of exposure. However, biomarker assessment has typically depended on in-person sample collection. The current study examined whether young adults in a national sample would be willing and able to provide a saliva sample via mail, and the correspondence of cotinine in the saliva sample with self-reported vaping and smoking.Methods: Data collection for the Monitoring the Future (MTF) Vaping Supplement was from September to November 2020. Eligible participants (N = 4358) were selected from a nationally-representative sample of US 12th-grade students in MTF in spring 2019. The MTF Vaping Supplement surveyed individuals nationally about one year after the 12th grade MTF survey (in 2020, mean age = 19.6 years; N =1244). Survey weights accounted for design and attrition.Results: Of those surveyed, 66.2% consented to provide a saliva sample and, of those, 73.8% mailed a sample. There were no significant differences in providing a saliva sample across any demographic characteristic, but those who reported nicotine use were less likely to provide a sample. Cotinine cut-off measures of > 3 ng/mL and > 10 ng/mL had good correspondence with self-reported measures.Conclusions: Results support the feasibility of collecting saliva via the mail in a national sample and the validity of data collected in this way. These findings support future research innovations to expand existing survey research protocols to include biomarker data collection in representative samples of young adults.