Validity of repeated-measures analyses of in vitro arthroplasty kinematics and kinetics.
Validity of repeated-measures analyses of in vitro arthroplasty kinematics and kinetics.
复制标题
体外关节成形术运动学和动力学重复测量分析的有效性。
DOI：
10.1016/j.jbiomech.2021.110669
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发表时间：
2021
影响因子：
2.4
通讯作者：
Dandridge O
中科院分区：
文献类型：
--
作者：
Dandridge O
关节成形术的体外模型能够进行临床前测试并为临床决策提供信息。重复测量比较最大限度地提高资源效率，但其有效性，而不测试顺序随机化是未知的。本研究旨在确定膝关节和髋关节置换术的尸体模型是否存在任何大的检验顺序效应。首先，评估测试顺序对全膝关节置换术（TKA）生物力学的影响。将植入自体膝关节（仅TKA）的TKA（N = 3）的伸展力矩与部分膝关节置换术（TKA-last）不同组合后测试的TKA（N = 24）数据集进行比较。在36小时内重复测试同一膝关节5次对髌股和胫股运动学的影响也被量化。其次，评估了全髋关节置换术（THA）后测试顺序对关节囊韧带功能的影响。从先前发表的数据集中删除随机化，以创建增加和减少的头部尺寸组，并与t检验进行比较。在整个膝关节屈曲/伸展范围内，所有三个仅TKA伸展力矩均在TKA最后一个膝关节的95% CI内。重复测试导致均方根运动学误差在1 mm、1°或<总活动度的5%内。THA后，在增大（p = 0.01）和减小（p < 0.001）组中，较小的头部尺寸导致更大的松弛。测试顺序对使用体外尸体模型测量的膝关节或髋关节置换术生物力学没有大的影响。
In vitro models of arthroplasty enable pre-clinical testing and inform clinical decision making. Repeated-measures comparisons maximise resource efficiency, but their validity without testing order randomisation is not known. This study aimed to identify if there were any large testing order effects for cadaveric models of knee and hip arthroplasty. First, the effect of testing order on total knee arthroplasty (TKA) biomechanics was assessed. Extension moments for TKAs (N = 3) implanted into the native knee (TKA-only) were compared to a dataset of TKAs (N = 24) tested after different combinations of partial knee arthroplasty (TKA-last). The effect of repeatedly testing the same knee five times over 36 h on patellofemoral and tibiofemoral kinematics was also quantified. Second, the effect of testing order on capsular ligament function after total hip arthroplasty (THA) was assessed. Randomisation was removed from a previously published dataset to create increasing and decreasing head size groups, which were compared with t-tests.All three TKA-only extension moments fell within the 95% CI of the TKA-last knees across the full range of knee flexion/extension. Repeated testing resulted in root-mean-squared kinematics errors within 1 mm, 1°, or < 5 % of total range of motion. Following THA, smaller head-size resulted in greater laxity in both the increasing (p = 0.01) and decreasing (p < 0.001) groups. Testing order did not have large effects on either knee or hip arthroplasty biomechanics measured with in vitro cadaveric models.
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