Demonstration of Bartonella grahamii DNA in ocular fluids of a patient with neuroretinitis
Demonstration of Bartonella grahamii DNA in ocular fluids of a patient with neuroretinitis
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DOI：
10.1128/jcm.37.12.4034-4038.1999
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发表时间：
1999-12-01
影响因子：
9.4
通讯作者：
Rothova, A
中科院分区：
文献类型：
--
作者：
Kerkhoff, FT;Bergmans, AMC;Rothova, A
我们描述了一名55岁的人类免疫缺陷病毒阴性的女性患者的临床和实验室特征，她表现为双侧眼内炎症性疾病（神经视网膜炎型）和由巴尔通体感染引起的行为改变。诊断是基于从眼内液中提取的DNA的PCR分析。PCR产物的DNA序列分析表明，其与B的16 S rRNA基因序列100%同源。格拉汉姆。患者成功接受多西环素（200 mg/天）和利福平（600 mg/天）治疗4周。这是第一份报告，证明存在巴尔通体属的眼内液中的非免疫功能低下的病人，并表明B。格雷厄姆氏菌对人类是致病性的。
We describe the clinical and laboratory features of a 55-year-old human immunodeficiency virus-negative female patient who presented with bilateral intraocular inflammatory disease (neuroretinitis type) and behavioral changes caused by a Bartonella grahamii infection. Diagnosis was based on the PCR analysis of DNA extracted from the intraocular fluids. DNA analysis of the PCR product revealed a 100% identity with the 16S rRNA gene sequence of B. grahamii. The patient was successfully treated with doxycycline (200 mg/day) and rifampin (600 mg/day) for 4 weeks. This is the first report that demonstrates the presence of a Bartonella species in the intraocular fluids of a nonimmunocompromised patient and that indicates that B. grahamii is pathogenic for humans.