Presenting the characteristics, smoking versus diabetes, and outcome among patients hospitalized with COVID-19
Presenting the characteristics, smoking versus diabetes, and outcome among patients hospitalized with COVID-19
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DOI：
10.1002/jmv.26487
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发表时间：
2020-09-28
影响因子：
12.7
通讯作者：
Al Khames Aga, Luma A.
中科院分区：
文献类型：
--
作者：
Abbas, Hassan M.;Nassir, Kawthar F.;Al Khames Aga, Luma A.
方法从2020年5月1日至2020年6月25日，我们对284例新冠肺炎患者进行了横断面观察性随访，包括健康患者、吸烟者、糖尿病患者和糖尿病合并吸烟者。分析该病的临床特点、严重程度、病程和转归。结果新冠肺炎患者年龄18~80岁，中位数48岁，女性占33.80%。常见症状有发热(85.56%)、气短(49.65%)、咳嗽(45.42%)、头痛(40.86%)。与健康患者、糖尿病患者和吸烟者相比，患有一种以上共病(糖尿病和吸烟)的患者表现为危重病例。与糖尿病患者和糖尿病+吸烟患者相比，吸烟者的死亡率较低，而且吸烟的风险低于糖尿病患者。尽管吸烟者的死亡率高于健康患者(4.22%，危险比[HR]，1.358；95%可信区间[CI]，1.542-1.100；p=.014)，但低于糖尿病患者(7.04%，HR 1.531，95%CI：1.668-1.337，p=.000)和糖尿病加吸烟者(10.00%，HR，1.659；95%CI，1.763-1.510；p=.000)。结论多发合并症与新冠肺炎的病情进展及较高的病死率密切相关。吸烟者表现为轻度病例，而糖尿病和糖尿病+吸烟患者表现为重度至危重病例。尽管与健康患者相比，吸烟者的死亡率更高，但与糖尿病和糖尿病+吸烟患者相比，这一数字较小。
Methods We designed a cross-sectional, observational follow-up for 284 COVID-19 patients involving healthy patients, smokers, diabetics, and diabetic plus smokers recruited from May 1, 2020 to June 25, 2020. The clinical features, severity, duration, and outcome of the disease were analyzed. Results Of 284 COVID-19 patients, the median age was 48 years (range, 18-80), and 33.80% were female. Common symptoms included fever (85.56%), shortness of breath (49.65%), cough (45.42%), and headache (40.86%). Patients with more than one comorbidity (diabetes and smoking) presented as severe-critical cases compared to healthy patients, diabetics, and smokers. Smokers presented with a lower rate of death in comparison to diabetic patients and diabetic + smoking, furthermore, smoking was less risky than diabetes. Although the mortality rate was high in patients with smokers compared to healthy patients (4.22%, the hazard ratio [HR], 1.358; 95% confidence interval [CI], 1.542-1.100;p = .014), it was less than in diabetics (7.04%, HR 1.531, 95% CI: 1.668-1.337,p = .000), and diabetic plus smoker (10.00%, HR, 1.659; 95% CI, 1.763-1.510;p = .000). Conclusion Multiple comorbidities are closely related to the severity of COVID-19 disease progression and the higher mortality rate. Smokers presented as mild cases compared to diabetic and diabetic + smoking patients, who presented as severe to critical cases. Although a higher death rate in smokers was seen compared with healthy patients, this was smaller when compared to diabetic and diabetic + smoking patients.