Self-assembly and drug delivery studies of pH/thermo-sensitive polyampholytic (A-co-B)-b-C-b-(A-co-B) segmented terpolymers
Self-assembly and drug delivery studies of pH/thermo-sensitive polyampholytic (A-co-B)-b-C-b-(A-co-B) segmented terpolymers
复制标题
DOI：
10.1039/c1sm06185b
复制
发表时间：
2011-11
期刊：
影响因子：
3.4
通讯作者：
Z. Iatridi;G. Mattheolabakis;K. Avgoustakis;C. Tsitsilianis
中科院分区：
文献类型：
--
作者：
Z. Iatridi;G. Mattheolabakis;K. Avgoustakis;C. Tsitsilianis
通过静态和动态光散射、透射电镜和流变学研究了pH和热响应性聚（2-（二乙基氨基）甲基丙烯酸乙酯-共甲基丙烯酸）-b-（乙二醇甲基丙烯酸甲酯）-b-聚（2-（二乙基氨基）甲基丙烯酸乙酯-共甲基丙烯酸）(P（DEAEMA-co-MAA)-b- pegma -b-P(DEAEMA-co-MAA)）三嵌段三元共聚物在水溶液中的行为。在聚两性聚合物外层块的等电点区域观察到缔合现象，导致花状胶束，在较高的聚合物浓度下，形成三维瞬态胶束网络，由于PEGMA中间块的热敏性，表现出复杂的热响应。将多柔比星（DOX）药物装入三元共聚物胶束中，并进行药物释放研究。三聚体胶束对人脐静脉内皮细胞具有良好的细胞相容性。
We investigated the behavior of the pH and thermo-responsive poly(2-(diethylamino)ethyl methacrylate-co-methacrylic acid)-b-(ethylene glycol methyl ether methacrylate)-b-poly(2-(diethylamino)ethyl methacrylate-co-methacrylic acid) (P(DEAEMA-co-MAA)-b-PEGMA-b-P(DEAEMA-co-MAA)) triblock terpolymers in aqueous solution by means of static and dynamic light scattering, transmission electron microscopy and rheology. Association phenomena were observed at the isoelectric point region of the polyampholyte outer blocks leading to flower-like micelles and at higher polymer concentrations, to a three dimensional transient micellar network, exhibiting a compex thermo-response thanks to the thermo-sensitivity of the PEGMA middle block. Doxorubicin (DOX) drug was loaded in the terpolymer micelles and drug release studies were performed. Controlled drug delivery could be achieved by tuning pH. The terpolymer micelles exhibited satisfactory cytocompatibility towards human umbilical vein endothelial cells.