Hodgkin's Lymphoma: A Review of Neurologic Complications.
Hodgkin's Lymphoma: A Review of Neurologic Complications.
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DOI：
10.1155/2011/624578
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发表时间：
2011
影响因子：
--
通讯作者：
Chamberlain M
中科院分区：
文献类型：
--
作者：
Grimm S;Chamberlain M
霍奇金淋巴瘤是一种主要为B细胞系的血淋巴样肿瘤，具有独特的组织学、免疫表型和临床特征。霍奇金淋巴瘤的神经系统并发症可分为直接由疾病引起的，间接由疾病引起的，或由治疗引起的。霍奇金淋巴瘤的直接神经功能障碍源于转移性颅内脊髓疾病、硬膜外转移引起脊髓/马尾受压、脑膜外转移或硬膜内髓内脊髓转移。间接神经功能障碍可由副肿瘤疾病（如副肿瘤小脑变性或边缘脑炎）和中枢神经系统的原发性脉管炎引起。霍奇金淋巴瘤的治疗通常包括化疗或放疗，伴有影响神经系统的潜在治疗相关并发症。由地幔场放射治疗引起的神经系统并发症包括“垂头综合征”、急性臂丛病和短暂性脑缺血发作/脑梗死。霍奇金淋巴瘤的化疗可能导致脑梗死（由于蒽环类药物引起的心肌病栓塞）和周围神经病变。
Hodgkin's lymphoma is a hematolymphoid neoplasm, primarily of B cell lineage, that has unique histologic, immunophenotypic, and clinical features. Neurologic complications of Hodgkin's Lymphoma can be separated into those that result directly from the disease, indirectly from the disease, or from its treatment. Direct neurologic dysfunction from Hodgkin's Lymphoma results from metastatic intracranial spinal disease, epidural metastases causing spinal cord/cauda equina compression, leptomeningeal metastases, or intradural intramedullary spinal cord metastases. Indirect neurologic dysfunction may be caused by paraneoplastic disorders (such as paraneoplastic cerebellar degeneration or limbic encephalitis) and primary angiitis of the central nervous system. Hodgkin's lymphoma treatment typically includes chemotherapy or radiotherapy with potential treatment-related complications affecting the nervous system. Neurologic complications resulting from mantle-field radiotherapy include the “dropped head syndrome,” acute brachial plexopathy, and transient ischemic attacks/cerebral infarcts. Chemotherapy for Hodgkin's lymphoma may cause cerebral infarction (due to emboli from anthracycline-induced cardiomyopathy) and peripheral neuropathy.