Biomedical, lifestyle and psychosocial characteristics of people newly diagnosed with Type 2 diabetes: baseline data from the DESMOND randomized controlled trial
Biomedical, lifestyle and psychosocial characteristics of people newly diagnosed with Type 2 diabetes: baseline data from the DESMOND randomized controlled trial
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DOI：
10.1111/j.1464-5491.2008.02620.x
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发表时间：
2008-12-01
影响因子：
3.5
通讯作者：
Davies, M. J.
中科院分区：
文献类型：
--
作者：
Khunti, K.;Skinner, T. C.;Davies, M. J.
为了描述新诊断的2型糖尿病（T2 DM）患者的特征，并将其与已发表的研究进行比较，使用了在英格兰和苏格兰13个地点进行的DESMOND随机对照试验招募的参与者的基线数据。诊断后4周内收集了生物医学测量和心理特征问卷。在转介的1109名参与者中，824人同意参与（74.3%）。平均（+/- sd）年龄为59.5 +/- 12岁，54.9%为男性。平均HbA（1c）为8.1 ± 2.1%，性别间无差异。女性的平均体重指数（BMI）明显高于男性（33.7对31.3 kg/m2; P < 0.001）; 69%的女性和54%的男性肥胖（BMI > 30 kg/m2）。女性的总胆固醇显著较高（5.6对5.2 mmol/l; P < 0.001）。总体而言，14.7%的人报告吸烟。报告推荐的剧烈活动（>= 3次/周）和中度活动（>= 5次/周）的比例分别为10.6%和16.0%，女性较低。具体的疾病信念包括73%的人不清楚症状，只有54%的人认为糖尿病是一种严重的疾病。抑郁症状的女性患者明显多于男性患者（16.1% vs. 8.2%; P = 0.001）。来自这个新诊断的T2 DM患者的大型代表性队列的数据显示，许多人具有可改变的心血管危险因素。与文献的比较表明，新诊断的人的情况可能正在发生变化，HbA（1c）较低，肥胖患病率较高。许多人表达了对糖尿病的信念和不了解，需要解决这些问题，以便他们进行有效的自我管理。25，1454 - 1461（2008）。
To describe the characteristics of newly diagnosed people with Type 2 diabetes (T2DM) and compare these with published studies.Baseline data of participants recruited to the DESMOND randomized controlled trial conducted in 13 sites across England and Scotland were used. Biomedical measures and questionnaires on psychological characteristics were collected within 4 weeks of diagnosis.Of 1109 participants referred, 824 consented to participate (74.3%). Mean (+/- sd) age was 59.5 +/- 12 years and 54.9% were male. Mean HbA(1c) was 8.1 +/- 2.1% and did not differ by gender. Mean body mass index (BMI) was significantly higher in women (33.7 vs. 31.3 kg/m(2); P < 0.001); 69% of women and 54% of men were obese (BMI > 30 kg/m(2)). Total cholesterol was significantly higher in women (5.6 vs. 5.2 mmol/l; P < 0.001). Overall, 14.7% reported smoking. Percentages reporting recommended levels of vigorous activity (>= 3 times/week) and moderate activity (>= 5 times/week) were 10.6 and 16.0%, respectively, and were lower in women. Specific illness beliefs included 73% being unclear about symptoms and only 54% believing diabetes is a serious condition. Symptoms indicative of depression were reported by significantly more women than men (16.1% vs. 8.2%; P = 0.001).Data from this large and representative cohort of newly diagnosed people with T2DM show that many have modifiable cardiovascular risk factors. Comparison with the literature suggests that the profile of the newly diagnosed may be changing, with lower HbA(1c) and higher prevalence of obesity. Many expressed beliefs about and poor understanding of their diabetes that need to be addressed in order for them to engage in effective self-management.Diabet. Med. 25, 1454 -1461 (2008).