Maternal hematological and virological characteristics during early feline immunodeficiency virus (FIV) infection of cats as predictors of fetal infection and reproductive outcome at early gestation
Maternal hematological and virological characteristics during early feline immunodeficiency virus (FIV) infection of cats as predictors of fetal infection and reproductive outcome at early gestation
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DOI：
10.1016/j.vetimm.2009.04.011
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发表时间：
2009-10-15
影响因子：
1.8
通讯作者：
Coats, Karen S.
中科院分区：
文献类型：
--
作者：
Boudreaux, Crystal E.;Lockett, Nikki N.;Coats, Karen S.
FIV感染的猫是HIV母婴传播（MTCT）的小动物模型，因为这两种慢病毒在生物学上是相关的，并且产生相似的临床症状。这两种病毒都是垂直传播的，可能对生殖结果产生负面影响。孕产妇血液学和病毒学参数是艾滋病毒感染妇女母婴传播的预测因素。我们的目的是确定在FIV感染的猫怀孕早期相似的母体特征是否影响妊娠结局。我们用FIV-B-2542接种了10只猫; 10只猫未接种。我们定量纵向CD4：CD8 T细胞比率、前病毒载量和血浆病毒血症，监测纵向血清状态，并记录妊娠早期的临床和生殖结局。接种的蜂王在感染后第4周（p.i.）血清学阳性和前病毒阳性。感染后3.5个月，感染组的CD4：CD8比值降低。在整个感染过程中，动物的前病毒载量是可变的;所有动物的血浆病毒血症均低于检测水平。减少窝仔数和增加胎儿死亡发生在感染皇后。在从感染的蜂王收集的代表性胎盘（14/14; 100%）和胎儿（12/14; 86%）中检测到病毒RNA，但未检测到前病毒DNA。然而，母亲的病毒学和血液学特征与生殖结果没有正相关或负相关。由爱思唯尔公司出版
The FIV-infected cat is a small animal model for HIV mother-to-child transmission (MTCT) because the two lentiviruses are biologically related and produce similar clinical syndromes. Both viruses are vertically transmissible and may negatively impact reproductive outcome. Maternal hematological and virological parameters are predictors of MTCT in HIV-infected women. Our purpose was to determine whether similar maternal characteristics during early pregnancy in FIV-infected cats influence pregnancy outcome. We inoculated 10 cats with FIV-B-2542; 10 cats were uninoculated. We quantified longitudinal CD4:CD8 T cell ratios, proviral load, and plasma viremia, monitored longitudinal serostatus, and documented clinical and reproductive outcome during early pregnancy. Inoculated queens were seropositive and provirus positive by week 4 post-infection (p.i.). CD4:CD8 ratios were depressed in the infected group by month 3.5 p.i. Proviral load was variable in the animals throughout the course of infection; plasma viremia was below the level of detection in all animals. Reduced litter sizes and increased fetal demise occurred in infected queens. Viral RNA but not proviral DNA, was detected in representative placentas (14 of 14; 100%) and fetuses (12 of 14; 86%) collected from infected queens. However, maternal virological and hematological characteristics did not correlate either positively or negatively with reproductive outcome. Published by Elsevier B.V.