REAPPRAISAL OF FORCES INVOLVED IN HEMAGGLUTINATION
REAPPRAISAL OF FORCES INVOLVED IN HEMAGGLUTINATION
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DOI：
10.1159/000231805
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发表时间：
1977-01-01
期刊：
影响因子：
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通讯作者：
RECKEL, RP
中科院分区：
文献类型：
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作者：
POLLACK, W;RECKEL, RP
对1965年描述的控制第二阶段血凝反应的基本原理进行了评价。这种重新评价再次确认红细胞聚集依赖于势能势垒（ζ）。在红细胞之间。这又取决于体相介质的离子强度和介电常数。通过IG[免疫球蛋白]G和IgM抗体的血细胞凝集是这些IG的有效长度和ζ的函数。反应混合物中的细胞。细胞的凝集发生在当ζ-潜力低于临界水平。天然和合成聚合物的增强作用（例如，牛白蛋白）是为了降低ζ。通过提高体介质的介电常数。其他几个最近的概念进行了讨论，并根据现有的数据讨论的主要差异。
The underlying principles governing the 2nd stage of hemagglutination, as described in 1965, were evaluated. This reappraisal reaffirms that red cell aggregation is dependent on the potential energy barrier (.zeta.) between erythrocytes. This in turn is dependent on the ionic strength and dielectric constant of the bulk medium. Hemagglutination by Ig[immunoglobulin]G and IgM antibody is a function of the effective length of these Ig and the .zeta. of the cells in the reaction mixture. Agglutination of cells occurs when the .zeta.-potential is below a critical level. The enhancing action of natural and synthetic polymers (e.g., bovine albumin) is to lower .zeta. by raising the dielectric constant of the bulk medium. Several other recent concepts are discussed and the major differences discussed in light of data available.