Temporal encoding of place sequences by hippocampal cell assemblies
Temporal encoding of place sequences by hippocampal cell assemblies
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DOI：
10.1016/j.neuron.2006.02.023
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发表时间：
2006-04-06
期刊：
影响因子：
16.2
通讯作者：
Buzsáki, G
中科院分区：
文献类型：
--
作者：
Dragoi, G;Buzsáki, G
情景记忆和空间导航都需要对事件或地点之间的关系进行时间编码。在线性迷宫中，有序的空间距离之间的顺序位置表示的时间关系的海马位置细胞对内的周期θ振荡压缩的方式。这种相关性可能是由于共同的θ起搏器驱动的独立神经元的尖峰“相位进动”或特定海马细胞组装之间的时间协调的结果。我们发现，位置细胞对之间的时间相关性强于独立神经元的起搏器驱动所预测的，这表明在位置序列表示中突触相互作用和精确定时在细胞组装内和跨细胞组装中的关键作用。CA1和CA3合奏，确定空间位置，积极优先对相反阶段的θ周期。这些观察结果表明，交错CA3神经元序列绑定CA1组件代表重叠的过去，现在和未来的位置到单个事件。
Both episodic memory and spatial navigation require temporal encoding of the relationships between events or locations. In a linear maze, ordered spatial distances between sequential locations were represented by the temporal relations of hippocampal place cell pairs within cycles of theta oscillation in a compressed manner. Such correlations could arise due to spike "phase precession" of independent neurons driven by common theta pacemaker or as a result of temporal coordination among specific hippocampal cell assemblies. We found that temporal correlation between place cell pairs was stronger than predicted by a pacemaker drive of independent neurons, indicating a critical role for synaptic interactions and precise timing within and across cell assemblies in place sequence representation. CA1 and CA3 ensembles, identifying spatial locations, were active preferentially on opposite phases of theta cycles. These observations suggest that interleaving CA3 neuronal sequences bind CA1 assemblies representing overlapping past, present, and future locations into single episodes.