Increased Synaptic Dopamine in the Putamen in Restless Legs Syndrome
Increased Synaptic Dopamine in the Putamen in Restless Legs Syndrome
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DOI：
10.5665/sleep.2300
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发表时间：
2013-01-01
期刊：
影响因子：
5.6
通讯作者：
Allen, Richard P.
中科院分区：
文献类型：
--
作者：
Earley, Christopher J.;Kuwabara, Hiroto;Allen, Richard P.
研究目标：先前使用正电子发射断层扫描（PET）或单光子发射计算机断层扫描技术的研究报告了不宁腿综合征（RLS）患者和对照患者之间纹状体多巴胺-2受体（D2 R）结合电位（BP）差异的不一致结果。D2 R-BP确实反映了受体-配体相互作用，如受体亲和力（Kd）和密度（β（max））或神经递质突触浓度。因此，D2 R-BP的差异反映了这些主要因素的变化。PET技术目前可用于估计D2 R β（最大值）和K-d。设计：单独的早晨和晚上进行PET扫描。研究对象：31例原发性RLS患者和36例年龄和性别相匹配的对照组患者完成了本研究，测量和结果：RLS患者在壳核和尾状核的D2 R-BP较低，但腹侧纹状体的D2 R-BP较低。对那些以前没有服用多巴胺能药物的RLS患者进行的亚组分析继续显示后壳核的D2 R-BP显著降低。两组的D2 R-BP在夜间和白天之间没有差异。D2 R β（max）和K-d在RLS患者和对照患者之间没有显著差异，但在夜间腹侧纹状体确实显示出强烈和显著的增加。疾病状态的主要和次要临床措施未能显示任何关系到D2 R在任何大脑regions.Conclusions：鉴于缺乏任何差异，无论是β（最大）或K-D和先前的研究支持增加突触前多巴胺能活性，目前发现的D2 R-BP的变化可能反映了突触多巴胺的增加。
Study Objectives: Prior studies using positron emission tomography (PET) or single-photon emission computed tomography techniques have reported inconsistent findings regarding differences between patients with restless legs syndrome (RLS) and control patients in the striatal dopa-mine- 2 receptor (D2R) binding potentials (BP). D2R-BP does reflect receptor-ligand interactions such as receptor affinity (K-d) and density (beta(max)) or neurotransmitter synaptic concentrations. Thus, differences in D2R-BP reflect changes in these primary factors. PET techniques are currently available to estimate D2R beta(max) and K-d.Design: Separate morning and evening PET scans were performed. The D2R-BP were measured in basal ganglia using [C-11] raclopride.Setting: Academic medical center.Patients or Participants: Thirty-one patients with primary RLS and 36 age-and sex-matched control patients completed the study.Measures and Results: Patients with RLS had lower D2R-BP in putamen and caudate but not the ventral striatum. A subgroups analysis of those RLS patients who had not previously taken dopaminergic medications continued to show a significantly lower D2R-BP in the posterior putamen. D2R-BP did not differ between night and day for either group. D2R beta(max) and K-d did not differ significantly between patients with RLS and control patients but did show a strong and significant increase at night in the ventral striatum. Primary and secondary clinical measures of disease status failed to show any relation to D2R in any brain region.Conclusions: Given the lack of any difference in either beta(max) or K-d and the prior studies supporting an increase in presynaptic dopaminergic activity, the current changes found in D2R-BP likely reflect an increase in synaptic dopamine.