Reconfiguration of brain network architecture to support executive control in aging.
Reconfiguration of brain network architecture to support executive control in aging.
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DOI：
10.1016/j.neurobiolaging.2016.04.003
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发表时间：
2016-08
影响因子：
4.2
通讯作者：
D'Esposito M
中科院分区：
文献类型：
--
作者：
Gallen CL;Turner GR;Adnan A;D'Esposito M
衰老伴随着执行控制能力的下降和底层大脑网络结构的变化。在这里，我们检查了年轻人和老年人在无任务静息状态和 N-back 任务期间的大脑网络，并研究了大脑模块化网络组织中与年龄相关的变化。与年轻人相比，老年人在静息状态和任务之间的网络组织表现出更大的变化。虽然年轻人在最困难的任务条件下表现出侧额叶区域和其他网络模块之间的连接性增加，但老年人在要求较低的任务条件下也表现出这种连接性增加的模式。此外，老年人模块间连接性的增加与更快的任务表现和更大的上纵束分数各向异性（FA）有关。这些结果表明，在静息状态和任务之间表现出更明显的网络变化的老年人具有更好的执行控制性能和核心额后白质通路的更大结构连接。
Aging is accompanied by declines in executive control abilities and changes in underlying brain network architecture. Here, we examined brain networks in young and older adults during a task-free resting-state and an N-back task and investigated age-related changes in the modular network organization of the brain. Compared to young adults, older adults showed larger changes in network organization between resting-state and task. While young adults exhibited increased connectivity between lateral frontal regions and other network modules during the most difficult task condition, older adults also exhibited this pattern of increased connectivity during less demanding task conditions. Moreover, the increase in between-module connectivity in older adults was related to faster task performance and greater fractional anisotropy (FA) of the superior longitudinal fasciculus. These results demonstrate that older adults who exhibit more pronounced network changes between a resting-state and task have better executive control performance and greater structural connectivity of a core frontal-posterior white matter pathway.