Visible-Light-Induced Radical Cyclization of Trifluoroacetimidoyl Chlorides with Alkynes: Catalytic Synthesis of 2-Trifluoromethyl Quinolines
Visible-Light-Induced Radical Cyclization of Trifluoroacetimidoyl Chlorides with Alkynes: Catalytic Synthesis of 2-Trifluoromethyl Quinolines
复制标题
可见光诱导三氟乙酰亚胺酰氯与炔烃的自由基环化：催化合成 2-三氟甲基喹啉
DOI：
10.1002/chem.201303149
复制
发表时间：
2013-12-09
影响因子：
4.3
通讯作者：
Zhou, Lei
中科院分区：
文献类型：
--
作者：
Dong, Xichang;Xu, Youwei;Zhou, Lei
本文报道了一种简便、有效的合成2-三氟甲基喹啉的方法，即三氟乙酰亚胺酰氯与炔发生可见光引发的自由基环化反应。该方案允许通过在温和和环境友好的条件下使用光氧化还原催化剂活化C（sp2）Cl-键来产生亚氨酰基自由基（参见方案）。
A simple and efficient method for the synthesis of 2‐trifluoromethyl quinolines by means of visible‐light‐induced radical cyclization of trifluoroacetimidoyl chlorides with alkynes has been developed. This protocol allows the generation of imidoyl radicals by activation of C (sp2) Cl bonds using a photoredox catalyst under mild and environmentally friendly conditions (see scheme).