Decreased expression of NDRG1 is correlated with tumor progression and poor prognosis in patients with esophageal squamous cell carcinoma
Decreased expression of NDRG1 is correlated with tumor progression and poor prognosis in patients with esophageal squamous cell carcinoma
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DOI：
10.1111/j.1442-2050.2006.00618.x
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发表时间：
2006-01-01
影响因子：
2.6
通讯作者：
Kuwabara, Y.
中科院分区：
文献类型：
--
作者：
Ando, T.;Ishiguro, H.;Kuwabara, Y.
NDRG 1（N-myc downstream regulated gene-1）是p53介导的细胞凋亡所必需的基因，受PTEN（phosphatase and tensin homolog）调控。在几种癌症中，它被认为是一种肿瘤抑制基因。其在食管鳞状细胞癌（ESCC）中的意义尚未研究。本研究旨在探讨NDRG 1在食管癌组织中的表达及其与食管癌临床病理和生物学因素的关系，并探讨NDRG 1表达与食管癌预后的关系。采用实时荧光定量RT-PCR方法检测47例食管鳞癌组织中NDRG 1 mRNA的表达。参考临床病理因素分析数据。在食管癌组织中，NDRG 1 mRNA表达在更晚期的病理分期（0-I vs. II-IV; P = 0.0027）和局部肿瘤浸润（T1-2 vs. T3-4; P = 0.0136）中显著较低。NDRG 1 mRNA低表达患者术后生存期明显短于NDRG 1 mRNA高表达患者（对数秩检验，P = 0.0478）。NDRG 1表达受损可能导致ESCC侵袭性增强。
NDRG1 (N-myc downstream regulated gene-1) was reported to be necessary for p53-mediated apoptosis and to be regulated by PTEN (phosphatase and tensin homolog). In several cancers, it was suggested to be a tumor suppressor gene. Its significance in esophageal squamous cell carcinoma (ESCC) has not been studied. The objective of this study was to clarify the relation between clinicopathological and biologic factors in esophageal carcinoma and to determine the prognostic significance of the expression of NDRG1. Expression of NDRG1 mRNA was quantified by real-time reverse transcription polymerase chain reaction using a Lightcycler in 47 esophageal ESCC specimens. The data were analyzed with reference to clinicopathological factors. Among the esophageal cancer tissues, NDRG1 mRNA expression was significantly lower in tumors of more advanced pathological stage (0-I vs. II-IV; P = 0.0027) and local tumor invasion (T1-2 vs. T3-4; P = 0.0136). Patients who had low NDRG1 mRNA expression had a significantly shorter survival after surgery compared with patients who had high NDRG1 mRNA expression (log-rank test, P = 0.0478). Impaired NDRG1 expression may lead to more aggressive invasion of ESCC.