Recognition of stage-specific mycobacterial antigens differentiates between acute and latent infections with Mycobacterium tuberculosis
Recognition of stage-specific mycobacterial antigens differentiates between acute and latent infections with Mycobacterium tuberculosis
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DOI：
10.1128/cvi.13.2.179-186.2006
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发表时间：
2006-02-01
影响因子：
--
通讯作者：
Doherty, TM
中科院分区：
文献类型：
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作者：
Demissie, A;Leyten, EMS;Doherty, TM
据估计，结核分枝杆菌每年感染8000万至1亿人，其中大多数人不发展为临床结核病（TB），而是将感染维持在潜伏状态。这些人通常在结核菌素皮肤试验中呈阳性反应，并可能在以后发展为临床结核病，特别是如果他们的免疫系统受损。潜伏感染者之所以有趣，有两个原因。首先，它们是M.结核病，这需要考虑结核病控制。第二，如果在疾病复发之前检测到，它们代表了对M产生保护性免疫应答的人群。结核病，这是非常重要的定义相关的保护性免疫。在这项研究中，我们表明，虽然对早期分泌抗原靶6的反应性是M。在结核病感染中，对16-kDa Rv 2031 c抗原（HspX或α-晶状体蛋白）的强烈应答主要限于潜伏感染的个体，提供了鉴别结核病的免疫诊断或针对结核病的治疗性疫苗接种的可能性。
Mycobacterium tuberculosis is estimated to infect 80 to 100 million people annually, the majority of whom do not develop clinical tuberculosis (TB) but instead maintain the infection in a latent state. These individuals generally become positive in response to a tuberculin skin test and may develop clinical TB at a later date, particularly if their immune systems are compromised. Latently infected individuals are interesting for two reasons. First, they are an important reservoir of M. tuberculosis, which needs to be considered for TB control. Second, if detected prior to recrudescence of the disease, they represent a human population that is making a protective immune response to M. tuberculosis, which is very important for defining correlates of protective immunity. In this study, we show that while responsiveness to early secretory antigenic target 6 is a good marker for M. tuberculosis infection, a strong response to the 16-kDa Rv2031c antigen (HspX or alpha-crystallin) is largely restricted to latently infected individuals, offering the possibility of differential immunodiagnosis of, or therapeutic vaccination against, TB.