The impact of age, weight and gender on BDNF levels in human platelets and plasma
The impact of age, weight and gender on BDNF levels in human platelets and plasma
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DOI：
10.1016/j.neurobiolaging.2004.03.002
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发表时间：
2005-01-01
影响因子：
4.2
通讯作者：
Virchow, JC
中科院分区：
文献类型：
--
作者：
Lommatzsch, M;Zingler, D;Virchow, JC
脑源性神经营养因子（BDNF）是成人神经元可塑性的关键介质。已知BDNF储存在人血小板中并在血浆中循环，但对BDNF在外周血中的调节和功能仍知之甚少。在这项前瞻性研究中，我们检查了140名健康，非过敏性成年人（20-60岁），以阐明年龄和身体参数对人血小板和血浆中BDNF水平的影响。BDNF在血清（中位数：22.6 ng/ml）、血小板（中位数：92.7 pg/10（6）血小板）和血浆（中位数：92.5 pg/ml）中的浓度范围较宽。血浆中BDNF水平随年龄或体重的增加而显著下降，而血小板水平则无此变化。当体重匹配时，BDNF血浆水平没有显着的性别差异。然而，女性的血小板BDNF水平明显低于男性。此外，血小板BDNF水平在月经周期中发生变化。总之，我们证明了年龄或性别等参数对外周血中储存和循环的BDNF水平有特定的影响。(C)2004年爱思唯尔公司All rights reserved.
Brain-derived neurotrophic factor (BDNF) is a key mediator of neuronal plasticity in the adult. BDNF is known to be stored in human platelets and to circulate in plasma, but the regulation and function of BDNF in peripheral blood is still poorly understood. In this prospective study, we have examined 140 healthy, non-allergic adults (20-60 years old) to elucidate the impact of age and physical parameters on BDNF levels in human platelets and plasma. There was a wide concentration range of BDNF in serum (median: 22.6 ng/ml), platelets (median: 92.7 pg/10(6) platelets) and plasma (median: 92.5 pg/ml). BDNF levels in plasma decreased significantly with increasing age or weight, whereas platelet levels did not. When matched for weight, there were no significant gender differences regarding BDNF plasma levels. However, women displayed significantly lower platelet BDNF levels than men. In addition, platelet BDNF levels changed during the menstrual cycle. In conclusion, we demonstrate that parameters such as age or gender have a specific impact on stored and circulating BDNF levels in peripheral blood. (C) 2004 Elsevier Inc. All rights reserved.