Novel lactic acid-based natural deep eutectic solvents: Efficiency in the ultrasound-assisted extraction of antioxidant polyphenols from common native Greek medicinal plants
Novel lactic acid-based natural deep eutectic solvents: Efficiency in the ultrasound-assisted extraction of antioxidant polyphenols from common native Greek medicinal plants
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DOI：
10.1016/j.jarmap.2016.03.003
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发表时间：
2016-09-01
影响因子：
3.9
通讯作者：
Makris, Dimitris P.
中科院分区：
文献类型：
--
作者：
Bakirtzi, Christina;Triantafyllidou, Katerina;Makris, Dimitris P.
选择希腊本土药用植物，包括白藓，茴香，马郁兰，薄荷和鼠尾草，被用来测试一些新的乳酸为基础的天然低共熔溶剂（NADES）提取多酚类化合物的效率。在超声处理下进行浸提，低共熔混合物（作为80%（v/v）水溶液进行测试）为乳酸：氯化胆碱、乳酸：乙酸钠、乳酸：乙酸铵和乳酸：甘氨酸：水，相应摩尔比为3：1、3：1、3：1和3：1：3。后三个NADES是首次报告。水和60%（v/v）乙醇水溶液也用作对照溶剂。所得结果证明乳酸：甘氨酸：水表现出高效率，但在某些情况下，乳酸：乙酸钠和乳酸：乙酸铵同样有效。数据还表明，具有高多酚浓度的提取物也可能具有较高的抗自由基活性和还原能力。NADES测试是无毒的，可再生的和非常有效的溶剂从药用植物多酚回收。这项研究的结果解释的假设的基础上的极性的NADES测试。(C)2016 Elsevier GmbH. All rights reserved.
Selected native Greek medicinal plants, including dittany, fennel, marjoram, mint and sage, were used to test the efficiency of some novel lactic acid-based natural deep eutectic solvents (NADES) to extract polyphenolic compounds. Extractions were performed under ultrasonication and the eutectic mixtures, tested as 80% (v/v) aqueous solutions, were lactic acid:choline chloride, lactic acid:sodium acetate, lactic acid:ammonium acetate and lactic acid:glycine:water, with corresponding molar ratios of 3:1, 3:1, 3:1 and 3:1:3. The three latter NADES are reported for the first time. Water and 60% (v/v) aqueous ethanol were also used as control solvents. The results obtained evidenced that lactic acid:glycine:water exhibited high efficiency, but in some instances lactic acid:sodium acetate and lactic acid:ammonium acetate were equally efficient. The data also suggested that extracts with high polyphenol concentration may also possess higher antiradical activity and reducing power. The NADES tested are non-toxic, renewable and exceptionally efficient solvents for polyphenol recovery from medicinal plants. The findings of this study were interpreted on the ground of assumptions regarding the polarity of the NADES tested. (C) 2016 Elsevier GmbH. All rights reserved.