Protective effect of myo-inositol hexaphosphate (phytate) on bone mass loss in postmenopausal women
Protective effect of myo-inositol hexaphosphate (phytate) on bone mass loss in postmenopausal women
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DOI：
10.1007/s00394-012-0377-6
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发表时间：
2013-03-01
影响因子：
5
通讯作者：
Perello, Joan
中科院分区：
文献类型：
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作者：
Lopez-Gonzalez, Angel A.;Grases, Felix;Perello, Joan
本研究旨在探讨绝经后妇女尿InsP6水平与骨量丢失及骨折风险的关系。157例绝经后妇女中，70例尿植酸值偏低(0.76亩)，42例中值(0.76~1.42亩)，45例尿植酸值高(1.42亩/千分之1.42)。在注册时和12个月后(腰椎和股骨颈)测量颈部的密度测量值，并使用工具FRAX(A(R))计算10年骨折风险。InsP6水平低的个体腰椎骨量损失(3.08+/-A 0.65%对0.43+/-A 0.55%)显著高于植酸水平高的个体。此外，InsP6水平低的女性比InsP6水平高的女性表现出超过2%的腰椎骨量损失(55.6%比20.7%)。在髋部(0.37+/-A0.06%比0.18+/-A0.04%)和主要骨质疏松性骨折(2.45+/-A0.24%比1.83+/-A0.11%)中，低植酸组的10年骨折概率也显著高于高植酸组。可以得出结论：高尿植酸浓度与12个月后腰椎骨量丢失减少以及髋部和主要骨质疏松性骨折的10年概率降低相关，表明增加植酸盐摄入量可以防止骨质疏松的发展。
The objective of this paper was to evaluate the relationship between urinary concentrations of InsP6, bone mass loss and risk fracture in postmenopausal women.A total of 157 postmenopausal women were included in the study: 70 had low (a parts per thousand currency sign0.76 mu M), 42 intermediate (0.76-1.42 mu M) and 45 high (a parts per thousand yen1.42 mu M) urinary phytate concentrations. Densitometry values for neck were measured at enrollment and after 12 months (lumbar spine and femoral neck), and 10-year risk fracture was calculated using the tool FRAX(A (R)).Individuals with low InsP6 levels had significantly greater bone mass loss in the lumbar spine (3.08 +/- A 0.65 % vs. 0.43 +/- A 0.55 %) than did those with high phytate levels. Moreover, a significantly greater percentage of women with low than with high InsP6 levels showed more than 2 % of bone mass loss in the lumbar spine (55.6 vs. 20.7 %). The 10-year fracture probability was also significantly higher in the low-phytate group compared to the high-phytate group, both in hip (0.37 +/- A 0.06 % vs 0.18 +/- A 0.04 %) and major osteoporotic fracture (2.45 +/- A 0.24 % vs 1.83 +/- A 0.11 %).It can be concluded that high urinary phytate concentrations are correlated with reduced bone mass loss in lumbar spine over 12 months and with reduced 10-year probability of hip and major osteoporotic fracture, indicating that increased phytate consumption can prevent development of osteoporosis.