GATA-4/5/6, a subfamily of three transcription factors transcribed in developing heart and gut.
GATA-4/5/6, a subfamily of three transcription factors transcribed in developing heart and gut.
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发表时间：
1994-09
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通讯作者：
A. Laverriere;C. Macneill;Charles Wendell Mueller;R. Poelmann;J. Burch;T. Evans
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作者：
A. Laverriere;C. Macneill;Charles Wendell Mueller;R. Poelmann;J. Burch;T. Evans
我们描述的实验表明：1）两个先前确定的成员的加塔家族的转录因子（两者最初都被称为加塔-4）对应于两个不同因子的鸡cDNA（我们现在称之为cGATA-4和cGATA-5）; 2）该家族的另一个新成员对应于命名为cGATA-6的第三因子; 3）这些mRNA中的每一种都显示出差异表达模式。cGATA-5基因最初在原始心管形成之前在心脏新月体中转录。在原始心脏形成后，cGATA-5转录物在内皮细胞和心肌以及其他侧板衍生物中是明显的。cGATA-5基因也在原始胚胎肠道中转录，并且在晚期胚胎中，随着它们经历终末分化，cGATA-5基因在胃肠道上皮的不同区段中依次上调。因此，这些研究为加塔-5的组织特异性调节以及这三个家族成员可能重叠的调节功能提供了新的见解。
We describe experiments which show that: 1) two previously identified members of the GATA family of transcription factors (both of which were originally called GATA-4) correspond to chicken cDNAs for two distinct factors (which we now refer to as cGATA-4 and cGATA-5); 2) another new member of this family corresponds to a third factor designated cGATA-6; 3) each of these mRNAs displays a differential expression pattern. The cGATA-5 gene is initially transcribed in the cardiac crescent prior to formation of the primordial heart tube. Following formation of the primitive heart, cGATA-5 transcripts are evident in both endocardium and myocardium as well as in other lateral plate derivatives. The cGATA-5 gene is also transcribed in the primitive embryonic gut and in late stage embryos is sequentially up-regulated in distinct segments of gastrointestinal epithelia as they undergo terminal differentiation. These studies thus provide novel insights into tissue-specific regulation by GATA-5, as well as into possibly overlapping regulatory functions for these three family members.